SNCA and DYRK1A

Number of citations of the paper that reports this interaction (PubMedID 16959772)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		SNCA	DYRK1A
Description		synuclein alpha	dual specificity tyrosine phosphorylation regulated kinase 1A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Cytosol Ribosome Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Actin Cytoskeleton Membrane Inclusion Body Axon Growth Cone Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Synapse Perinuclear Region Of Cytoplasm Presynapse Postsynapse Supramolecular Fiber	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Neurofilament Actin Filament Nuclear Speck Axon Dendrite Ribonucleoprotein Complex
	Molecular Function	SNARE Binding Magnesium Ion Binding Transcription Cis-regulatory Region Binding Actin Binding Enzyme Inhibitor Activity Protein Kinase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Microtubule Binding Enzyme Activator Activity Ferrous Iron Binding Zinc Ion Binding Lipid Binding Oxidoreductase Activity Kinesin Binding Enzyme Binding Protein Domain Specific Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Phospholipase Binding Metal Ion Binding Tau Protein Binding Beta-tubulin Binding Phosphoprotein Binding Molecular Adaptor Activity Phospholipase D Inhibitor Activity Dynein Complex Binding Protein Sequestering Activity Transporter Regulator Activity Cuprous Ion Binding	Nucleotide Binding Transcription Coactivator Activity Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Cytoskeletal Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Tubulin Binding Kinase Activity Transferase Activity Identical Protein Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H3T45 Kinase Activity Splicing Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Receptor Recycling Positive Regulation Of Neurotransmitter Secretion Synaptic Transmission, Dopaminergic Fatty Acid Metabolic Process Neutral Lipid Metabolic Process Phospholipid Metabolic Process Glutathione Metabolic Process Mitochondrial Membrane Organization Chemical Synaptic Transmission Neurotransmitter Secretion Adult Locomotory Behavior Response To Xenobiotic Stimulus Response To Iron(II) Ion Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Response To Lipopolysaccharide Response To Type II Interferon Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of SNARE Complex Assembly Regulation Of Locomotion Response To Cocaine Dopamine Biosynthetic Process Dopamine Metabolic Process Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Positive Regulation Of Exocytosis Negative Regulation Of Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Behavioral Response To Cocaine Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Positive Regulation Of Inflammatory Response Positive Regulation Of Synaptic Transmission Synapse Organization Regulation Of Acyl-CoA Biosynthetic Process Protein Complex Oligomerization Protein Tetramerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Regulation Of Norepinephrine Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Positive Regulation Of Inositol Phosphate Biosynthetic Process Membrane Organization Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Supramolecular Fiber Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Desipramine Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Presynapse Assembly Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Negative Regulation Of Heterochromatin Formation Positive Regulation Of RNA Splicing Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Amyloid-beta Formation Regulation Of Neurofibrillary Tangle Assembly
Pathways		Amyloid fiber formation PKR-mediated signaling	G0 and Early G1
Drugs		Resveratrol Dequalinium Copper	N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Anxiety ( 33859377) Blood protein levels ( 30072576) Dementia with Lewy bodies ( 29263008) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Feeling nervous ( 29500382) Neurociticism ( 29500382) Parkinson's disease ( 28892059 34064523 32310270 32201043 31660654 19915575 28011712 21084426 19915576 20070850 20711177 21044948 21292315 21738487 22438815 22451204 24511991 25064009 27182965) Parkinson's disease (age of onset) ( 30957308 31660654 33884653) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to bupropion in depression ( 27622933)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) HIV-1 replication ( 21364930) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Neutrophil count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316) Systolic blood pressure ( 32902719) White blood cell count ( 32888494)
Interacting Genes		419 interacting genes: A1BG ACAP1 ACKR2 ACTA1 ACTR1A ADAP2 ADM ADORA2A ADRB2 AGO2 AKT1 AMBRA1 ANGPT1 ANXA2 ANXA6 AP1G2 AP2M1 APBB1 APLP1 APOC2 APOC3 APOE APP ARAP2 ARAP3 ARF1 ARF3 ARF5 ARF6 ARFGAP1 ARFGAP2 ARFGAP3 ARHGAP15 ARPP19 ARRB1 ARRB2 ARSA ASGR1 ASGR2 ATP13A1 AXIN2 B4GALT1 BAD BAG5 BASP1 BCL2L1 BCL6 BDH2 BET1 CACFD1 CACNB4 CACNG5 CACYBP CALM1 CALU CAMK1D CAP1 CAV1 CAV2 CAV3 CBLC CBS CCL3 CCR1 CDC42 CDC42EP2 CDC42EP3 CDC42SE1 CDH13 CDK4 CHMP1B CHMP2A CHMP2B CHMP4B CHMP6 CHRM3 CHRM4 CHRM5 CHRNA4 CHRNB2 CHRND CKB CLEC10A CLEC4M CLSTN2 CLTB CLTCL1 CNIH2 CNN3 CNST COL25A1 COLEC11 COLQ COPG1 CPEB1 CPLX4 CPNE1 CPNE3 CRIPT CRYAB CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CSNK2A1 CSNK2A2 CTNND1 CTSD CXCL16 CYCS CYTH2 CYTH3 CYTH4 DBH DDX1 DDX17 DLG3 DMTN DNAJA1 DNAJC5 DNM1 DNM3 DOCK7 DOLPP1 DTNB DVL1 DYRK1A EDC4 EEF1D EGFR EGR1 EGR3 EHD3 EIF3C EIF3G EIF3L ELK1 ELMO3 ELMOD3 ENC1 ENSA EPN2 ERBB3 ERGIC2 ERGIC3 EXOC1 F2R FAM120A FAM98A FBXL5 FBXW7 FGFR4 FGR FOLR3 FSHR FTH1 FYN GAB2 GABARAPL1 GABRA4 GAD1 GBA1 GHRH GNAI1 GNAI3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GULP1 H1-1 H1-2 H2AC11 HFE HOMER3 HSD17B4 HSPA1B HSPA6 HSPA8 HSPB2 HSPB6 HSPB8 HTR1B ICA1 IQSEC2 ITSN2 KAT2A KAT2B KCNJ10 KCNMB4 KDR KIAA1191 KLC1 KLK6 LAMP2 LDLRAP1 LEFTY2 LGALS3 LILRB1 LIN7B LIN7C LRFN2 LRP12 LRPAP1 LRRC15 LRRC4 LYN MAP1B MAP1LC3B MAP4K2 MAPK1 MAPK8 MAPK8IP1 MAPKAPK5 MAPT MARCO MDM2 MEF2D MLC1 MME MMRN1 MS4A2 MSR1 MT-CO1 MT-CO3 MVB12A MYH9 MYLK2 MYO6 NAP1L1 NECAP1 NECAP2 NEDD4 NEDD4L NKD2 NME1 NRP1 OPTN OSBPL11 OSBPL5 OSBPL7 PABPC1 PACSIN1 PAICS PAK3 PARD6A PARK7 PATL1 PCLO PDCD6IP PDE4DIP PDIA2 PDLIM7 PELP1 PF4 PHACTR1 PHETA1 PIAS3 PIK3CD PIP5K1B PIP5K1C PLAT PLCB2 PLD1 PLG PLK1 PLK3 PLS3 PML POPDC1 PPP3CA PRDX1 PREP PRKAR1A PRKCE PRKN PSD3 PSMA1 PSMB1 PTBP1 PTK2B PTPN18 PTPN6 PTPRR PTX3 QARS1 RAB11A RAB11B RAB11FIP1 RAB11FIP2 RAB17 RAB1A RAB20 RAB26 RAB3A RAB4A RAB5A RAB5B RAB5C RABAC1 RABEP1 RAC1 RALA RASGRP2 RBBP4 RET RHOA RHOBTB3 RNF10 ROPN1B RPH3AL RPL18A RPL22 RPS12 RPS25 RUFY1 S100A9 SAMD4A SAP30BP SCAMP1 SCARA5 SCYL1 SDF4 SELE SEMA4F SEPTIN2 SEPTIN3 SEPTIN4 SFRP4 SH3BP4 SIAH2 SLC22A2 SLC30A8 SLC35E2B SLC5A7 SLC6A1 SLC6A15 SLC6A20 SLC6A3 SLC6A7 SMAP2 SMURF2 SNCAIP SNCB SNX1 SNX16 SPAG9 SPTBN1 SQSTM1 SRC SRI ST13 STAM STAMBP STUB1 STX11 STX18 STX1B STX2 STXBP3 SYK SYN1 SYN3 SYPL2 SYT3 SYTL4 TFG TFRC TGFB2 TGM1 TGM2 TH TOM1 TOMM20 TOR1A TPPP TPRG1L TRAPPC2 TRAPPC6B TRIP11 TRPV6 TSG101 TUBA1A TXLNA UBA52 UBB UBC UBE2D2 UBE2W UBL3 USP2 USP33 USP47 USP7 USP8 VAMP2 VCP VPS13C VPS25 VPS28 VPS29 VPS36 VPS37D VPS45 VPS4A VTA1 WASHC2A WTAP YOD1 YTHDF1 YTHDF2 YWHAB YWHAE YWHAH ZRANB1	145 interacting genes: - ABCA2 ABHD12 ADAM19 ADAM22 ADAM23 ADAM9 ADAMTS1 ADAMTS9 AGAP1 AMPH APP ASTN2 ATRN ATRNL1 CACHD1 CCN1 CCNL2 CEP70 CFH CKAP5 CLASRP CLU CREB1 CRIM1 CTNNA1 CYLD DCAF5 DCHS2 DCTD DKK3 DNM1 DNM3 DROSHA DSCAM DSCAML1 DVL3 DYNLL1 EFEMP1 EFEMP2 EIF2B5 ENPP2 ERBB3 ERC1 FAM53C FBN1 FEZ1 FOXO1 GEMIN8 GLI1 GPR37L1 H2BC3 H3C1 H4C1 HMG20A ID2 ITGB8 JCAD KIF1A KPNA4 KPNA6 KPRP LAMB1 LATS2 LEO1 LIN52 LMO3 LRP1B LRP2 LRP4 LTBP3 MAGEH1 MAPT MEGF9 MIGA1 MTA1 MTA3 MYCBP2 MYT1L NAP1L1 NCAPH2 NECAB3 NELL1 NELL2 NPC1 NUCB1 OSBPL1A PCSK6 PEA15 PHYHIP PJA1 PLAUR PLP1 PNISR PRDM4 PRKN PSAP PTOV1 RAPGEF2 RB1 RBL1 RECK RNF169 RNF216 RNF220 RSBN1L SCRIB SF3B1 SMAD2 SNCA SNRNP70 SPRED1 SPRED2 SPRY2 SPTBN1 SRPK2 SRSF1 SRSF10 SRSF4 SRSF5 STAB1 STX1A SULF1 THBS1 TMEFF1 TMEM59 TNFRSF25 TRAF2 TRIM66 TROAP TSPYL2 USP13 USP32 USP34 USP54 USP7 VLDLR VPS54 WIF1 XRCC6 YWHAB YWHAE YWHAG ZBTB11 ZNF365
Entrez ID		6622	1859
HPRD ID		01227	09018
Ensembl ID		ENSG00000145335	ENSG00000157540
Uniprot IDs		H6UYS5 P37840	A0A2R8Y6I6 Q13627
PDB IDs		1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6H6B 6I42 6L1T 6L1U 6L4S 6LRQ 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB 6SST 6SSX 6UFR 6XYO 6XYP 6XYQ 7C1D 7E0F 7L7H 7LC9 7NCA 7NCG 7NCH 7NCI 7NCJ 7NCK 7OZG 7OZH 7STX 7UAK 7V47 7V48 7V49 7V4A 7V4B 7V4C 7V4D 7WMM 7WNZ 7WO0 7XJX 7XO0 7XO1 7XO2 7XO3 7YK2 7YK8 7YNF 7YNG 7YNL 7YNM 7YNN 7YNO 7YNP 7YNQ 7YNR 7YNS 7YNT 8A4L 8A9L 8ADS 8ADU 8ADV 8ADW 8AEX 8B9V 8BQV 8BQW 8CE7 8CEB 8CYR 8CYS 8CYT 8CYV 8CYW 8CYX 8CYY 8CZ0 8CZ1 8CZ2 8CZ3 8CZ6 8FPT 8G0L 8GF7 8H03 8H04 8H05 8HZB 8HZC 8HZS 8JEX 8JEY 8JJV 8JLY 8OG0 8OJR 8OL8 8OQI 8PIX 8PJO 8PK2 8PK4 8QPZ 8RI9 8RQM 8RRR 8UKA 8X7B 8X7L 8X7M 8X7O 8X7P 8X7Q 8X7R 8XWD 8Y2P 8Y2Q 8ZLI 8ZLO 8ZLP 8ZMY 8ZWH 8ZWI 8ZWJ 8ZWK 9CD9 9CDA 9CK3 9CX6 9D5C 9EUU 9FYP 9HGR 9HGS 9HXA 9IJP	2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6LN1 6QU2 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J 6T6A 6UIP 6UWY 6YF8 7A4O 7A4R 7A4S 7A4W 7A4Z 7A51 7A52 7A53 7A55 7A5B 7A5D 7A5L 7A5N 7AJ2 7AJ4 7AJ5 7AJ7 7AJ8 7AJA 7AJM 7AJS 7AJV 7AJW 7AJY 7AK2 7AKA 7AKB 7AKE 7AKL 7FHS 7FHT 7O7K 7OY6 7Z5N 7ZH8 8C3G 8C3Q 8C3R 8R8E 8T2H 8YEV
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Import Into Cell Regulation Of Vesicle-mediated Transport Regulation Of Transport Plasma Membrane Intracellular Protein Localization Protein Transport Regulation Of Signaling Cytoplasm Establishment Of Protein Localization Regulation Of Cell Communication Establishment Of Localization In Cell Regulation Of Cellular Component Organization Synapse Endosome Membrane Regulation Of Endocytosis Cytosol Cellular Localization Vesicle Organization Extracellular Exosome Regulation Of Protein Localization Receptor-mediated Endocytosis Regulation Of Biological Quality Regulation Of Signal Transduction Regulation Of Secretion Intracellular Transport Regulation Of Secretion By Cell Positive Regulation Of Transport Membrane Organization Secretion Cytoplasmic Vesicle Exocytosis Multivesicular Body Assembly Secretion By Cell Positive Regulation Of Cellular Component Organization Multivesicular Body Organization Early Endosome Endosome Organization Presynapse Modulation Of Chemical Synaptic Transmission Intracellular Protein Transport Ubiquitin Protein Ligase Binding Endosomal Transport Positive Regulation Of Catabolic Process Organelle Localization Glutamatergic Synapse Regulation Of Intracellular Signal Transduction Regulation Of Cellular Localization	Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Signaling Regulation Of Multicellular Organismal Development Calcium Ion Binding Positive Regulation Of Developmental Process Positive Regulation Of Cell Communication Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Heparin Binding Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Developmental Process Negative Regulation Of Lens Fiber Cell Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Differentiation Integrin Binding Positive Regulation Of Programmed Cell Death Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Extracellular Region Apolipoprotein Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Neuron Projection Morphogenesis
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