SNCA and FYN

Number of citations of the paper that reports this interaction (PMID 15033366)
24

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study)
HPRD (in vivo, in vitro)

		SNCA	FYN
Gene Name		synuclein, alpha (non A4 component of amyloid precursor)	FYN proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Lysosome Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Ribosome Plasma Membrane Cell Cortex Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon Growth Cone Platelet Alpha Granule Membrane Terminal Bouton Fibril Perinuclear Region Of Cytoplasm	Nucleus Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft
	Molecular Function	Magnesium Ion Binding Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Microtubule Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Protein Domain Specific Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Phospholipase Binding Transcription Regulatory Region DNA Binding Dynein Binding Protein N-terminus Binding Tau Protein Binding Beta-tubulin Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity	G-protein Coupled Receptor Binding Glycoprotein Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Tubulin Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Phosphatidylinositol 3-kinase Binding Ion Channel Binding Metal Ion Binding Ephrin Receptor Binding Peptide Hormone Receptor Binding Growth Factor Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Microglial Cell Activation Positive Regulation Of Receptor Recycling Negative Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Fatty Acid Metabolic Process Neutral Lipid Metabolic Process Phospholipid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Membrane Organization Aging Adult Locomotory Behavior Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation Regulation Of Locomotion Dopamine Biosynthetic Process Response To Drug Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extracellular Fibril Organization Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Negative Regulation Of Dopamine Metabolic Process Behavioral Response To Cocaine Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synapse Organization Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Oxidation-reduction Process Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process	Neuron Migration Protein Phosphorylation Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Blood Coagulation Learning Feeding Behavior Regulation Of Cell Shape Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Cell Migration Cell Differentiation Platelet Activation Forebrain Development T Cell Costimulation Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Dendrite Morphogenesis Regulation Of Defense Response To Virus By Virus Activated T Cell Proliferation T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Amyloids	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease DCC mediated attractive signaling Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Nef and signal transduction Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Regulation of KIT signaling PI3K/AKT activation PI-3K cascade EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Signaling by PDGF DAP12 interactions GAB1 signalosome Host Interactions of HIV factors CD28 co-stimulation CD28 dependent PI3K/Akt signaling The role of Nef in HIV-1 replication and disease pathogenesis Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Signaling by VEGF Downstream signal transduction Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Platelet Adhesion to exposed collagen Axon guidance Costimulation by the CD28 family PIP3 activates AKT signaling HIV Infection VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Ephrin signaling EPH-ephrin mediated repulsion of cells PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR NCAM signaling for neurite out-growth Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Semaphorin interactions CTLA4 inhibitory signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer PECAM1 interactions CD28 dependent Vav1 pathway Signaling by FGFR Cell surface interactions at the vascular wall GPVI-mediated activation cascade
Drugs			Dasatinib 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
Diseases
GWAS		Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 22438815 20070850 21044948 21738487)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		110 interactors: A1BG ACTA1 ADAP2 ADRBK1 AKT1 ANXA6 APLP1 APP ARHGAP15 ARPP19 BAD BAG5 BAX BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 COL25A1 COX1 COX3 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CYCS DMTN DOCK7 DYNC1H1 DYRK1A EEF1A1 EIF3G ELK1 ENC1 ENSA FGR FKBP4 FYN GABARAPL1 GAPDH GRK1 GRK5 GRK6 GSK3B HSD17B4 HSP90AA1 HSPA1A HSPA8 HSPB1 HSPB2 HSPB6 HSPB8 IARS KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D NEDD4 NEDD4L PAK3 PARK2 PDE4DIP PELP1 PFDN2 PINK1 PLCB2 PLD1 PLK1 PLK2 PLK3 PRDX1 PRKCE PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPT4 SIAH1 SIAH2 SLC6A3 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI SUMO2 SYK SYN1 TGM1 TH TOR1A TUBA1A UBB UBC USP47 YWHAB YWHAE YWHAH	182 interactors: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DOK1 DOK3 DOK4 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 EVL FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB GAB3 GNB2L1 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B HNRNPK HRAS HSP90AA1 HTR6 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCP2 MAG MAP2 MAPT MCAM MED28 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RAF1 RPL10 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70
Entrez ID		6622	2534
HPRD ID		01227	00655
Ensembl ID		ENSG00000145335	ENSG00000010810
Uniprot IDs		H6UYS0 H6UYS5 P37840	P06241 Q5R3A8
PDB IDs		1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29	1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Localization Cell Death Death Regulation Of Cell Death Apoptotic Process Response To Abiotic Stimulus Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Intracellular Transport Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Proteolysis Positive Regulation Of Metabolic Process Response To Organic Substance Negative Regulation Of Apoptotic Process Nervous System Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stimulus System Development Negative Regulation Of Protein Metabolic Process Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Response To Stress Negative Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Death Cell Communication Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Signaling Intracellular Signal Transduction Positive Regulation Of Proteolysis Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To External Stimulus Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway	Signaling Signal Transduction Cell Communication Regulation Of Immune System Process Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Locomotion Regulation Of Signal Transduction Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Defense Response Positive Regulation Of Signal Transduction Innate Immune Response Cell Activation Blood Coagulation Antigen Receptor-mediated Signaling Pathway Hemostasis Fc Receptor Signaling Pathway Response To Wounding Response To Stress Wound Healing Response To Organic Substance Cell Migration Cell Differentiation Intracellular Signal Transduction Cell Motility Regulation Of Body Fluid Levels Response To External Stimulus Regulation Of Cellular Process Developmental Process Regulation Of Cell-cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorylation Anatomical Structure Development Regulation Of Cell Activation Regulation Of Cellular Component Organization
Tagcloud ?		2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically prdx2 predictedinteractions scrutinized searching slowing string sum tof	293t analyzing anchoring aspartate binds coclusters coexpressed family implicated involves learning lyn mediate member nmda nr2a participates plasticity promotes psd ptk ptks scaffold serving src substrate synaptic tyrosine yes
Tagcloud (Difference) ?		2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically prdx2 predictedinteractions scrutinized searching slowing string sum tof	293t analyzing anchoring aspartate binds coclusters coexpressed family implicated involves learning lyn mediate member nmda nr2a participates plasticity promotes psd ptk ptks scaffold serving src substrate synaptic tyrosine yes
Tagcloud (Intersection) ?