SMURF1 and SMAD7

Number of citations of the paper that reports this interaction (PubMedID 11278251)
0

Data Source:
HPRD (in vitro, in vivo)

		SMURF1	SMAD7
Description		SMAD specific E3 ubiquitin protein ligase 1	SMAD family member 7
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Extracellular Exosome	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phospholipid Binding Transferase Activity SMAD Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding Activin Receptor Binding	Transcription Corepressor Activity Protein Binding Collagen Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Metal Ion Binding I-SMAD Binding Activin Receptor Binding Transcription Regulator Inhibitor Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Export From Nucleus Ectoderm Development Protein Ubiquitination Cell Differentiation BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Receptor Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Axon Extension Wnt Signaling Pathway, Planar Cell Polarity Pathway Engulfment Of Target By Autophagosome Substrate Localization To Autophagosome Protein Targeting To Vacuole Involved In Autophagy Protein Localization To Plasma Membrane Positive Regulation Of Dendrite Extension Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Protein-containing Complex Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Protein-containing Complex Disassembly Adherens Junction Assembly Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Differentiation Artery Morphogenesis Protein Stabilization Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Beta-catenin Destruction Complex Disassembly Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases Interferon gamma signaling
Drugs
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 23128233 28067908) Lack of premeditation ( 30718321) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Ulcerative colitis ( 20228798 28067908)	Asthma ( 32296059) Atrial fibrillation ( 29892015 30061737) Colorectal cancer ( 24836286 29471430 29228715 17934461 30529582 26151821 25990418 24448986 23266556 31826910 21761138 18372905 18372901) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Creatinine levels ( 29403010) Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		188 interacting genes: ADRM1 ANAPC5 ANKRD13A ANKRD13D ANKRD50 ANKS4B ANXA6 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASCC2 ASH2L ATXN3 AVEN AXIN1 BMPR2 BTK BTRC C9orf78 CALCOCO1 CCDC69 CCM2 CDC40 CDK14 CDKL1 CSNK1D CSNK2A2 CTNNB1 CTNND1 CTTN CUEDC1 CUL5 CXXC1 DDX54 DNAJC7 DUSP13B DVL2 ECSIT ELOF1 ELP3 ENTR1 EPHA1 EPN1 ETV6 FAF2 FBXL15 FBXO3 FBXO30 FCHO1 FES FGF12 FGR FKBP3 FSCN1 FZR1 GNG11 GRIPAP1 GRK3 HDGFL3 HIP1 HOMER2 ILRUN IMPACT ING2 INPP5B IRAK2 ITGB1BP1 ITK JUNB KRT36 LATS1 LCK LHX9 LIMS1 LMNA LONRF3 MAP3K10 MAP3K2 MAP3K3 MAP3K9 MAP4K5 MARK2 MATK MINDY3 MSN NAA16 NDFIP2 NEDD8 NEK2 ODF2 OTUD6B OXSR1 PADI4 PAK1 PAK1IP1 PDGFRA PDLIM7 PICALM PIP5K1C PLEKHO1 POLR2A PRKCA PRKCG PRKCI PRR16 PSMD4 PSME3 PTEN PWP1 RABEP1 RAD23A RASD2 RBCK1 RHOA RHOB RHPN2 RIOK3 RIPK2 RIT1 RNF11 RNF114 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SCYL1 SENP8 SF3A1 SKIC8 SLAIN2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SQSTM1 SRSF4 SRSF5 STK31 STK35 STRAP STUB1 TAB1 TAOK3 TAPT1 TBK1 TLN1 TNIK TNIP2 TNK2 TNNT1 TOM1 TOM1L2 TRAF4 TRIP10 TTC17 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2K UBE2L3 UBE2M UBE2V1 UBQLN1 UBQLN2 UBTF UBXN1 UBXN6 UBXN7 USP45 USP9X WEE1 WFS1 XPO1 ZFAND5	58 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L PARD3 PIAS1 PIAS4 RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 USP2 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107
Entrez ID		57154	4092
HPRD ID		06902	04241
Ensembl ID		ENSG00000198742	ENSG00000101665
Uniprot IDs		Q9HCE7	B3KYA8 O15105
PDB IDs		2LAZ 2LB0 2LB1 2LTX 3PYC	2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
Enriched GO Terms of Interacting Partners?		Cytosol Protein Kinase Activity Modification-dependent Protein Catabolic Process Protein Modification Process Cytoplasm Proteolysis Involved In Protein Catabolic Process Kinase Activity Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Intracellular Signaling Cassette Macromolecule Catabolic Process Protein Serine Kinase Activity Proteolysis Post-translational Protein Modification Proteasomal Protein Catabolic Process ATP Binding Nucleus Regulation Of Proteasomal Protein Catabolic Process I-SMAD Binding Nucleotide Binding Macromolecule Metabolic Process Signal Transduction Regulation Of Proteolysis Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Nucleoplasm Protein Modification By Small Protein Conjugation Protein Phosphorylation Heteromeric SMAD Protein Complex Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Ubiquitin Binding Regulation Of Cell Communication Protein Polyubiquitination Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding	I-SMAD Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Binding Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication
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