SMURF1 and TLN1

Number of citations of the paper that reports this interaction (PubMedID 19363486)
35

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SMURF1	TLN1
Description		SMAD specific E3 ubiquitin protein ligase 1	talin 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Extracellular Exosome	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phospholipid Binding Transferase Activity SMAD Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding Activin Receptor Binding	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Export From Nucleus Ectoderm Development Protein Ubiquitination Cell Differentiation BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Receptor Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Axon Extension Wnt Signaling Pathway, Planar Cell Polarity Pathway Engulfment Of Target By Autophagosome Substrate Localization To Autophagosome Protein Targeting To Vacuole Involved In Autophagy Protein Localization To Plasma Membrane Positive Regulation Of Dendrite Extension Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 23128233 28067908) Lack of premeditation ( 30718321) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Ulcerative colitis ( 20228798 28067908)	Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		188 interacting genes: ADRM1 ANAPC5 ANKRD13A ANKRD13D ANKRD50 ANKS4B ANXA6 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASCC2 ASH2L ATXN3 AVEN AXIN1 BMPR2 BTK BTRC C9orf78 CALCOCO1 CCDC69 CCM2 CDC40 CDK14 CDKL1 CSNK1D CSNK2A2 CTNNB1 CTNND1 CTTN CUEDC1 CUL5 CXXC1 DDX54 DNAJC7 DUSP13B DVL2 ECSIT ELOF1 ELP3 ENTR1 EPHA1 EPN1 ETV6 FAF2 FBXL15 FBXO3 FBXO30 FCHO1 FES FGF12 FGR FKBP3 FSCN1 FZR1 GNG11 GRIPAP1 GRK3 HDGFL3 HIP1 HOMER2 ILRUN IMPACT ING2 INPP5B IRAK2 ITGB1BP1 ITK JUNB KRT36 LATS1 LCK LHX9 LIMS1 LMNA LONRF3 MAP3K10 MAP3K2 MAP3K3 MAP3K9 MAP4K5 MARK2 MATK MINDY3 MSN NAA16 NDFIP2 NEDD8 NEK2 ODF2 OTUD6B OXSR1 PADI4 PAK1 PAK1IP1 PDGFRA PDLIM7 PICALM PIP5K1C PLEKHO1 POLR2A PRKCA PRKCG PRKCI PRR16 PSMD4 PSME3 PTEN PWP1 RABEP1 RAD23A RASD2 RBCK1 RHOA RHOB RHPN2 RIOK3 RIPK2 RIT1 RNF11 RNF114 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SCYL1 SENP8 SF3A1 SKIC8 SLAIN2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SQSTM1 SRSF4 SRSF5 STK31 STK35 STRAP STUB1 TAB1 TAOK3 TAPT1 TBK1 TLN1 TNIK TNIP2 TNK2 TNNT1 TOM1 TOM1L2 TRAF4 TRIP10 TTC17 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2K UBE2L3 UBE2M UBE2V1 UBQLN1 UBQLN2 UBTF UBXN1 UBXN6 UBXN7 USP45 USP9X WEE1 WFS1 XPO1 ZFAND5	37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ
Entrez ID		57154	7094
HPRD ID		06902	01726
Ensembl ID		ENSG00000198742	ENSG00000137076
Uniprot IDs		Q9HCE7	Q9Y490
PDB IDs		2LAZ 2LB0 2LB1 2LTX 3PYC	1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?		Cytosol Protein Kinase Activity Modification-dependent Protein Catabolic Process Protein Modification Process Cytoplasm Proteolysis Involved In Protein Catabolic Process Kinase Activity Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Intracellular Signaling Cassette Macromolecule Catabolic Process Protein Serine Kinase Activity Proteolysis Post-translational Protein Modification Proteasomal Protein Catabolic Process ATP Binding Nucleus Regulation Of Proteasomal Protein Catabolic Process I-SMAD Binding Nucleotide Binding Macromolecule Metabolic Process Signal Transduction Regulation Of Proteolysis Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Nucleoplasm Protein Modification By Small Protein Conjugation Protein Phosphorylation Heteromeric SMAD Protein Complex Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Ubiquitin Binding Regulation Of Cell Communication Protein Polyubiquitination Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding	Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development
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