GRIA3 and NSF

Number of citations of the paper that reports this interaction (PMID 9697855)
72

Data Source:
HPRD (two hybrid)

		GRIA3	NSF
Gene Name		glutamate receptor, ionotropic, AMPA 3	N-ethylmaleimide-sensitive factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Postsynaptic Membrane	Cytoplasm Lysosomal Membrane Golgi Stack Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Extracellular Vesicular Exosome
	Molecular Function	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity	Protein Binding ATP Binding ATPase Activity Syntaxin-1 Binding Rab GTPase Binding Protein Kinase Binding PDZ Domain Binding Protein Complex Binding ATPase Activity, Coupled Metal Ion Binding
	Biological Process	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic	Positive Regulation Of Receptor Recycling Potassium Ion Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Synaptic Transmission Vesicle-mediated Transport Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Golgi Vesicle Docking
Pathways		Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Lithium Aniracetam
Diseases
GWAS			Parkinson's disease ( 19915575 21812969)
Protein-Protein Interactions		11 interactors: ADRB2 GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1	25 interactors: ARRB1 C14orf1 CD28 DRD2 EIF3E FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 KIAA1377 LUC7L2 NAPA NAPG PTPN9 RAMP3 RPLP1 STX1A STX4 STX8 USO1 VAPA
Entrez ID		2892	4905
HPRD ID		02378	03380
Ensembl ID		ENSG00000125675	ENSG00000073969
Uniprot IDs		P42263 Q17R51 Q5XKG2	P46459
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Vesicle-mediated Transport Intracellular Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Exocytosis Response To Extracellular Stimulus Protein Localization Cellular Response To Extracellular Stimulus Establishment Of Localization In Cell Regulation Of Signaling Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Cellular Localization Positive Regulation Of Phosphorylation Apoptotic Signaling Pathway Signal Transduction Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Enzyme Linked Receptor Protein Signaling Pathway Protein Localization To Membrane Neuron Development Response To External Stimulus Response To Nutrient Levels Regulation Of Cellular Localization Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Golgi Vesicle Docking Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Glial Cell Development Neuron Differentiation Cell Projection Organization Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Extracellular Vesicular Exosome Assembly Cellular Response To Starvation Positive Regulation Of Signal Transduction Cell Differentiation Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Granzyme-mediated Apoptotic Signaling Pathway	Membrane Fusion Membrane Organization Intracellular Transport Golgi Vesicle Transport Protein Localization Establishment Of Localization In Cell Protein Transport Synaptic Transmission Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Cell-cell Signaling Intracellular Protein Transport Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Cellular Protein Localization Neuron-neuron Synaptic Transmission Organelle Fusion Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Vesicle Organization Negative Regulation Of CAMP Biosynthetic Process Transport Mitochondrion Degradation Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Organelle Disassembly Synaptic Transmission, Glutamatergic Receptor Internalization Regulation Of Synaptic Vesicle Priming Regulation Of Protein Localization To Plasma Membrane Regulation Of Adenylate Cyclase Activity Regulation Of Vesicle-mediated Transport Regulation Of Cyclase Activity Regulation Of Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Cytoplasmic Transport Regulation Of Cellular Localization G-protein Coupled Receptor Internalization Regulation Of Peptide Hormone Secretion Cellular Component Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Receptor Metabolic Process Vesicle Docking Post-Golgi Vesicle-mediated Transport Regulation Of CAMP Biosynthetic Process Membrane Docking Regulation Of Protein Localization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles
Tagcloud (Intersection) ?