GRIA3 and GRIP2

Number of citations of the paper that reports this interaction (PubMedID 9768844)
0

Data Source:
HPRD (two hybrid)

		GRIA3	GRIP2
Description		glutamate ionotropic receptor AMPA type subunit 3	glutamate receptor interacting protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Postsynaptic Density Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Protein Homotetramerization Protein Heterotetramerization Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Potentiation Regulation Of Presynaptic Membrane Potential	Notch Signaling Pathway Artery Smooth Muscle Contraction Positive Regulation Of Blood Pressure Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules	Trafficking of GluR2-containing AMPA receptors
Drugs		Glutamic acid Butabarbital Ethanol Lithium cation Aniracetam Talampanel CX-717 Fluciclovine (18F) Lithium citrate Lithium succinate Lithium carbonate
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Mortality in sepsis ( 27639821)	Cognitive performance ( 19734545) Sjögren's syndrome ( 28076899)
Interacting Genes		13 interacting genes: ADRB2 CREBBP GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1 TSPAN7	6 interacting genes: CSPG4 FMR1 FXR1 GFI1B GRIA2 GRIA3
Entrez ID		2892	80852
HPRD ID		02378	18994
Ensembl ID		ENSG00000125675	ENSG00000144596
Uniprot IDs		P42263 Q17R51 Q5XKG2	Q9C0E4
PDB IDs			1V62 1X5R
Enriched GO Terms of Interacting Partners?		Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Endocytic Vesicle Membrane Establishment Of Protein Localization Postsynaptic Specialization, Intracellular Component Establishment Of Protein Localization To Membrane Localization Within Membrane Establishment Of Protein Localization To Plasma Membrane Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Intracellular Protein Transport Cellular Localization Establishment Of Localization In Cell Endosome To Plasma Membrane Protein Transport Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Neurotransmitter Receptor Transport Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Protein-containing Complex Binding Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Signal Transduction Intracellular Transport Vesicle-mediated Transport To The Plasma Membrane Regulation Of Biological Quality Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response-activating Signaling Pathway Temperature Homeostasis Lysosome Multicellular Organismal-level Homeostasis Regulation Of Protein Localization Regulation Of Exocytosis Protein Localization To Plasma Membrane Modulation Of Chemical Synaptic Transmission Synapse Ligand-gated Ion Channel Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Protein Sequestering Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Protein Localization To Cell Periphery	Dendritic Spine Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Glutamate Receptor Signaling Pathway RNA Strand Annealing Activity AMPA Glutamate Receptor Activity Intracellular Membraneless Organelle Positive Regulation Of Long-term Neuronal Synaptic Plasticity Glutamate-gated Receptor Activity Positive Regulation Of MiRNA-mediated Gene Silencing Modulation Of Chemical Synaptic Transmission Translation Regulator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing AMPA Glutamate Receptor Complex Regulation Of Post-transcriptional Gene Silencing Postsynapse Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Presynaptic Modulation Of Chemical Synaptic Transmission Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Synapse Molecular Condensate Scaffold Activity Regulation Of Neuronal Synaptic Plasticity Endocytic Vesicle Membrane Regulation Of Membrane Potential Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Intracellular Transport Of Viral Material Dendrite Amyloid-beta Binding Cytoplasmic Stress Granule Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Dendritic Filopodium Histone H3 Reader Activity MRNA Transport MRNA 3'-UTR Binding Negative Regulation Of Long-term Synaptic Depression Growth Cone Filopodium Positive Regulation Of Synaptic Transmission Ligand-gated Monoatomic Cation Channel Activity RNA Transport Positive Regulation Of Translation Monoatomic Ion Channel Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication
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