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GRIA3 and PPM1G
Number of citations of the paper that reports this interaction (PubMedID
14663150
)
35
Data Source:
HPRD
(in vitro, in vivo)
GRIA3
PPM1G
Description
glutamate ionotropic receptor AMPA type subunit 3
protein phosphatase, Mg2+/Mn2+ dependent 1G
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Membrane
Endocytic Vesicle Membrane
AMPA Glutamate Receptor Complex
Dendritic Spine
Synapse
Postsynaptic Membrane
Parallel Fiber To Purkinje Cell Synapse
Postsynaptic Density Membrane
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Molecular Function
Amyloid-beta Binding
Glutamate-gated Receptor Activity
AMPA Glutamate Receptor Activity
Monoatomic Ion Channel Activity
Ligand-gated Monoatomic Ion Channel Activity
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Hydrolase Activity
Cation Binding
Metal Ion Binding
Biological Process
Monoatomic Ion Transport
Glutamate Receptor Signaling Pathway
Calcium-mediated Signaling
Monoatomic Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Modulation Of Chemical Synaptic Transmission
Protein Homotetramerization
Protein Heterotetramerization
Regulation Of Postsynaptic Membrane Potential
Long-term Synaptic Potentiation
Regulation Of Presynaptic Membrane Potential
Protein Dephosphorylation
Signal Transduction
Peptidyl-threonine Dephosphorylation
Regulation Of Cell Cycle
Pathways
Activation of AMPA receptors
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Synaptic adhesion-like molecules
Drugs
Glutamic acid
Butabarbital
Ethanol
Lithium cation
Aniracetam
Talampanel
CX-717
Fluciclovine (18F)
Lithium citrate
Lithium succinate
Lithium carbonate
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Mortality in sepsis (
27639821
)
Bone mineral density (total hip) (
29883787
)
Creatinine levels (
31015462
)
Crohn's disease (
28067908
)
Hypertriglyceridemia (
23505323
)
Inflammatory bowel disease (
28067908
)
Non-oily fish consumption (
32066663
)
Takayasu arteritis (
25604533
)
Triglyceride levels (
31928498
)
Interacting Genes
13 interacting genes:
ADRB2
CREBBP
GRIA2
GRIP1
GRIP2
GZMB
LYN
NSF
PICK1
PPM1G
SDCBP
SQSTM1
TSPAN7
11 interacting genes:
FBXO38
GRIA3
H3-4
HEXIM1
LRPAP1
MSL1
MTNR1B
RN7SK
RPS6KA1
TERF1
TERF2
Entrez ID
2892
5496
HPRD ID
02378
09237
Ensembl ID
ENSG00000125675
ENSG00000115241
Uniprot IDs
P42263
Q17R51
Q5XKG2
O15355
Q6IAU5
PDB IDs
Enriched GO Terms of Interacting Partners
?
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Endocytic Vesicle Membrane
Establishment Of Protein Localization
Postsynaptic Specialization, Intracellular Component
Establishment Of Protein Localization To Membrane
Localization Within Membrane
Establishment Of Protein Localization To Plasma Membrane
Establishment Of Protein Localization To Postsynaptic Membrane
Neurotransmitter Receptor Transport To Postsynaptic Membrane
Neurotransmitter Receptor Transport To Plasma Membrane
Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Neurotransmitter Receptor Transport, Endosome To Plasma Membrane
Intracellular Protein Transport
Cellular Localization
Establishment Of Localization In Cell
Endosome To Plasma Membrane Protein Transport
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Neurotransmitter Receptor Transport
Protein Localization To Membrane
Protein Transport
Vesicle-mediated Transport
Protein-containing Complex Binding
Cellular Response To Lectin
Stimulatory C-type Lectin Receptor Signaling Pathway
Signal Transduction
Intracellular Transport
Vesicle-mediated Transport To The Plasma Membrane
Regulation Of Biological Quality
Ionotropic Glutamate Receptor Signaling Pathway
Ionotropic Glutamate Receptor Binding
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Localization To Postsynaptic Membrane
Protein Localization To Postsynapse
Regulation Of Toll-like Receptor 4 Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Temperature Homeostasis
Lysosome
Multicellular Organismal-level Homeostasis
Regulation Of Protein Localization
Regulation Of Exocytosis
Protein Localization To Plasma Membrane
Modulation Of Chemical Synaptic Transmission
Synapse
Ligand-gated Ion Channel Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Protein Sequestering Activity
Cell Surface Toll-like Receptor Signaling Pathway
Regulation Of Vesicle-mediated Transport
Protein Localization To Cell Periphery
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
7SK SnRNP
Shelterin Complex
Telomerase Activity
Nuclear Telomere Cap Complex
Telomeric D-loop Disassembly
Double-stranded Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
Telomeric Loop Disassembly
Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Transcription Elongation By RNA Polymerase II
RNA-templated DNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription, Elongation
Telomeric DNA Binding
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of DNA Biosynthetic Process
Chromosome, Telomeric Region
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Gamma-glutamyl Carboxylase Activity
Negative Regulation Of Establishment Of Protein Localization To Telomere
Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Positive Regulation Of Shelterin Complex Assembly
Telomere Cap Complex
Negative Regulation Of Telomere Maintenance Via Recombination
Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Telomere Single Strand Break Repair
Vitamin Binding
Negative Regulation Of Bone Development
Chemical Synaptic Transmission
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Chromosome Organization
Telomeric Loop Formation
Negative Regulation Of DNA Recombination At Telomere
Trans-synaptic Signaling
Synaptic Signaling
Regulation Of DNA Biosynthetic Process
Amyloid-beta Binding
DNA Biosynthetic Process
Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Testosterone Biosynthetic Process
Rough Endoplasmic Reticulum Lumen
Negative Regulation Of T-circle Formation
Telomere Maintenance
Positive Regulation Of Chromosome Organization
Regulation Of DNA-templated Transcription Elongation
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