NR1I2 and RBCK1

Number of citations of the paper that reports this interaction (PMID 23160820)
1

Data Source:
BioGRID (pull down)

		NR1I2	RBCK1
Gene Name		nuclear receptor subfamily 1, group I, member 2	RanBP-type and C3HC4-type zinc finger containing 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm	LUBAC Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Gene Expression Intracellular Receptor Signaling Pathway Exogenous Drug Catabolic Process Xenobiotic Transport Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Drug Export	Protein Polyubiquitination Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		Vitamin E Erlotinib Estradiol Ethinyl Estradiol Rifampin Rifaximin Paclitaxel Hyperforin SR12813 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Rilpivirine
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ACTN2 ATP6AP1 CHMP1A DYRK2 EIF3I FGR MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBR5	46 interactors: APP ARNT2 BACH1 CREBBP IKBKG IREB2 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PARK2 PCGF2 PRKCA PSMD4 RNF181 RNF31 SOCS6 SYCE1 TNFAIP3 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7
Entrez ID		8856	10616
HPRD ID		04346	16643
Ensembl ID		ENSG00000144852	ENSG00000125826
Uniprot IDs		F1D8P9 O75469	A6PVK0 Q9BYM8
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X	2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Regulation Of Metabolic Process Cell Communication Cellular Response To Hormone Stimulus Positive Regulation Of Metabolic Process Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Signal Transduction Response To Organic Substance Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Stimulus Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation RNA Metabolic Process Regulation Of Signal Transduction Cell Differentiation Regulation Of Cellular Process Response To Steroid Hormone Negative Regulation Of Cellular Metabolic Process Regulation Of Carbohydrate Metabolic Process Developmental Process Involved In Reproduction Regulation Of Signaling Gland Development Reproductive Structure Development Reproductive System Development In Utero Embryonic Development Mammary Gland Development Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Metabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Type I Interferon Production Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Response To Stress Regulation Of Proteolysis Histone Modification Histone Deubiquitination Cellular Response To Stress Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K11-linked Ubiquitination Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Chromosome Organization Protein K6-linked Ubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Protein Monoubiquitination Chromatin Modification Protein Autoubiquitination Negative Regulation Of Type I Interferon Production Cellular Process Regulation Of Transcription, DNA-templated
Tagcloud ?		1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl	1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin
Tagcloud (Difference) ?		1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl	1beta ali allocated attenuates autologous c3hc4 dependently dismutase histology intravenously malondialdehyde mda oalt occluded orthotopic oxidant pathologic peroxiredoxin portal prx ranbp restoring sham sod started u1 uh ul ulinastatin
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