NR1I2 and ATP6AP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NR1I2	ATP6AP1
Description		nuclear receptor subfamily 1 group I member 2	ATPase H+ transporting accessory protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Body Intermediate Filament Cytoskeleton	Golgi Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Endomembrane System Membrane Proton-transporting Two-sector ATPase Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Proton-transporting V-type ATPase Complex Synapse Extracellular Exosome Bounding Membrane Of Organelle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	ATPase Activator Activity Protein Binding Small GTPase Binding Transporter Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Positive Regulation Of Gene Expression Cell Differentiation Intracellular Receptor Signaling Pathway Xenobiotic Catabolic Process Xenobiotic Transport Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Structure Maintenance Cellular Response To Molecule Of Bacterial Origin	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Cellular PH Osteoclast Development Cellular Response To Increased Oxygen Levels Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Endosome To Plasma Membrane Protein Transport Proton Transmembrane Transport
Pathways			Insulin receptor recycling RHOA GTPase cycle Transferrin endocytosis and recycling Ion channel transport
Drugs		Vitamin E Oxiconazole Phenytoin Diethylstilbestrol Clotrimazole Pentobarbital Spironolactone Lindane Flutamide Ritonavir Erlotinib Cyclophosphamide Mephenytoin Carbamazepine Tamoxifen Warfarin Ethotoin Estradiol Mifepristone Methylphenobarbital Ethinylestradiol Ketoconazole Fenofibrate Rifampicin Clonazepam Miconazole Nifedipine Econazole Sulfinpyrazone Phenobarbital Ifosfamide Rifaximin Paclitaxel Dexamethasone Docetaxel Bezafibrate Genistein Prasterone Hyperforin Resveratrol Pregnenolone Quercetin SR12813 Afimoxifene Phenolphthalein Permethrin Dovitinib Chenodeoxycholic acid TO-901317 Hexestrol Triclosan Rilpivirine Pyrethrum extract Myrrh Piperine Troleandomycin Fenofibric acid Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate alpha-Tocopherol succinate D-alpha-Tocopherol acetate Dexamethasone acetate	Tiludronic acid
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol levels ( 32203549) Lymphocyte percentage of white cells ( 32888494) Total cholesterol levels ( 30275531)
Interacting Genes		34 interacting genes: ACTN2 ATP6AP1 CHMP1A DNMT3L DYRK2 EP300 FGR HNF4A MAPK7 MDM2 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NR0B2 NR5A2 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBE2I UBR5 YAP1	6 interacting genes: ANG ERBB2 HBA1 NR1I2 OGT RHOU
Entrez ID		8856	537
HPRD ID		04346	02184
Ensembl ID		ENSG00000144852	ENSG00000071553
Uniprot IDs		F1D8P9 O75469	A0A384MQW4 Q15904
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X 4NY9 4S0S 4S0T 4X1F 4X1G 4XAO 4XHD 5A86 5X0R 6BNS 6DUP 6HJ2 6HTY 6NX1 6P2B 6S41 6TFI 6XP9 7AX8 7AX9 7AXA 7AXB 7AXC 7AXD 7AXE 7AXF 7AXG 7AXH 7AXI 7AXJ 7AXK 7AXL 7N2A 7RIO 7RIU 7RIV 7YFK 8CCT 8CF9 8CH8 8E3N 8EQZ 8F5Y 8FPE 8SVN 8SVO 8SVP 8SVQ 8SVR 8SVS 8SVT 8SVU 8SVX 8SZV 9BEQ 9FZG 9FZH 9FZI 9FZJ	6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Hormone-mediated Signaling Pathway Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Intracellular Signal Transduction Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transcription Coactivator Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Rhythmic Process Nuclear Retinoid X Receptor Binding Cellular Developmental Process Nuclear Receptor Activity Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Gene Expression Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System	Nucleobase-containing Compound Catabolic Process Sulfur Compound Transmembrane Transporter Activity Positive Regulation Of Lipid Biosynthetic Process Fatty-acyl-CoA Transport Very Long-chain Fatty-acyl-CoA Metabolic Process Organophosphate Ester Transmembrane Transporter Activity Very Long-chain Fatty-acyl-CoA Catabolic Process Amide Transmembrane Transporter Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Nucleobase-containing Compound Transmembrane Transporter Activity Homeostatic Process ABC-type Fatty-acyl-CoA Transporter Activity Catabolic Process Cytosol Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process RNA Stabilization TRNA-specific Ribonuclease Activity Regulation Of Translation Cytoplasmic Stress Granule Membraneless Organelle Assembly Angiogenin-PRI Complex Negative Regulation Of Catabolic Process Regulation Of Protein Localization Translation Positive Regulation Of Establishment Of Protein Localization XPC Complex RNA Polymerase I Core Binding ERBB3:ERBB2 Complex Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Translation Haptoglobin Binding 5'-deoxynucleotidase Activity Adenosine Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translational Initiation TOR Signaling Positive Regulation Of Translational Initiation TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity Cellular Response To Rapamycin Regulation Of Translational Initiation Nucleoside Phosphate Catabolic Process Regulation Of Biological Quality Regulation Of Generation Of Precursor Metabolites And Energy Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Import Into Peroxisome Cytoplasmic Translation
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