NR1I2 and NFATC4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NR1I2	NFATC4
Description		nuclear receptor subfamily 1 group I member 2	nuclear factor of activated T cells 4
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Body Intermediate Filament Cytoskeleton	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Positive Regulation Of Gene Expression Cell Differentiation Intracellular Receptor Signaling Pathway Xenobiotic Catabolic Process Xenobiotic Transport Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Structure Maintenance Cellular Response To Molecule Of Bacterial Origin	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Synapse Maturation Long-term Synaptic Potentiation Cellular Response To Lithium Ion Vascular Associated Smooth Muscle Cell Development Negative Regulation Of MiRNA Transcription Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs		Vitamin E Oxiconazole Phenytoin Diethylstilbestrol Clotrimazole Pentobarbital Spironolactone Lindane Flutamide Ritonavir Erlotinib Cyclophosphamide Mephenytoin Carbamazepine Tamoxifen Warfarin Ethotoin Estradiol Mifepristone Methylphenobarbital Ethinylestradiol Ketoconazole Fenofibrate Rifampicin Clonazepam Miconazole Nifedipine Econazole Sulfinpyrazone Phenobarbital Ifosfamide Rifaximin Paclitaxel Dexamethasone Docetaxel Bezafibrate Genistein Prasterone Hyperforin Resveratrol Pregnenolone Quercetin SR12813 Afimoxifene Phenolphthalein Permethrin Dovitinib Chenodeoxycholic acid TO-901317 Hexestrol Triclosan Rilpivirine Pyrethrum extract Myrrh Piperine Troleandomycin Fenofibric acid Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate alpha-Tocopherol succinate D-alpha-Tocopherol acetate Dexamethasone acetate
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol levels ( 32203549) Lymphocyte percentage of white cells ( 32888494) Total cholesterol levels ( 30275531)	Appendicular lean mass ( 33097823) Diastolic blood pressure ( 27841878) Height ( 20881960 23563607 25282103) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		34 interacting genes: ACTN2 ATP6AP1 CHMP1A DNMT3L DYRK2 EP300 FGR HNF4A MAPK7 MDM2 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NR0B2 NR5A2 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBE2I UBR5 YAP1	12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ
Entrez ID		8856	4776
HPRD ID		04346	09096
Ensembl ID		ENSG00000144852	ENSG00000100968
Uniprot IDs		F1D8P9 O75469	Q14934
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X 4NY9 4S0S 4S0T 4X1F 4X1G 4XAO 4XHD 5A86 5X0R 6BNS 6DUP 6HJ2 6HTY 6NX1 6P2B 6S41 6TFI 6XP9 7AX8 7AX9 7AXA 7AXB 7AXC 7AXD 7AXE 7AXF 7AXG 7AXH 7AXI 7AXJ 7AXK 7AXL 7N2A 7RIO 7RIU 7RIV 7YFK 8CCT 8CF9 8CH8 8E3N 8EQZ 8F5Y 8FPE 8SVN 8SVO 8SVP 8SVQ 8SVR 8SVS 8SVT 8SVU 8SVX 8SZV 9BEQ 9FZG 9FZH 9FZI 9FZJ	2YRP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Hormone-mediated Signaling Pathway Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Intracellular Signal Transduction Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transcription Coactivator Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Rhythmic Process Nuclear Retinoid X Receptor Binding Cellular Developmental Process Nuclear Receptor Activity Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Gene Expression Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System	MAP Kinase Activity Protein Phosphatase Binding JUN Kinase Activity Regulation Of Protein Localization To Nucleus NFAT Protein Binding Response To Mechanical Stimulus Intracellular Signaling Cassette Response To Nutrient Levels Cellular Senescence Energy Homeostasis MAPK Cascade Positive Regulation Of Protein Localization To Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Cyclase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc-epsilon Receptor Signaling Pathway Response To UV Negative Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Immune Response Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Protein Localization Multicellular Organismal-level Homeostasis Regulation Of MRNA Stability Cellular Response To Molecule Of Bacterial Origin Canonical Inflammasome Complex Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Signal Transduction Nuclear Receptor Binding Rhythmic Process Cellular Response To Nutrient Levels Positive Regulation Of Macromolecule Biosynthetic Process Gamma-catenin-TCF7L2 Complex Fc Receptor Signaling Pathway JUN Phosphorylation Regulation Of Biological Quality
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