NR1I2 and NCOR2

Number of citations of the paper that reports this interaction (PMID 12072427)
16

Data Source:
BioGRID (pull down, pull down, two hybrid, two hybrid)
HPRD (two hybrid, in vivo, in vitro)

		NR1I2	NCOR2
Gene Name		nuclear receptor subfamily 1, group I, member 2	nuclear receptor corepressor 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Histone Deacetylase Binding Protein N-terminus Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Gene Expression Intracellular Receptor Signaling Pathway Exogenous Drug Catabolic Process Xenobiotic Transport Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Drug Export	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Chromatin organization HDACs deacetylate histones Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs		Vitamin E Erlotinib Estradiol Ethinyl Estradiol Rifampin Rifaximin Paclitaxel Hyperforin SR12813 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Rilpivirine
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Cognitive performance ( 19734545)
Protein-Protein Interactions		27 interactors: ACTN2 ATP6AP1 CHMP1A DYRK2 EIF3I FGR MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBR5	84 interactors: AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HIST1H4A HNF4A INPP5K IRF5 JUN MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16
Entrez ID		8856	9612
HPRD ID		04346	02910
Ensembl ID		ENSG00000144852	ENSG00000196498
Uniprot IDs		F1D8P9 O75469	C9J0Q5 C9JE98 C9JFD3 Q9Y618
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X	1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 3R29 3R2A 4A69
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Regulation Of Metabolic Process Cell Communication Cellular Response To Hormone Stimulus Positive Regulation Of Metabolic Process Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Signal Transduction Response To Organic Substance Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Stimulus Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation RNA Metabolic Process Regulation Of Signal Transduction Cell Differentiation Regulation Of Cellular Process Response To Steroid Hormone Negative Regulation Of Cellular Metabolic Process Regulation Of Carbohydrate Metabolic Process Developmental Process Involved In Reproduction Regulation Of Signaling Gland Development Reproductive Structure Development Reproductive System Development In Utero Embryonic Development Mammary Gland Development Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Organic Substance Hormone-mediated Signaling Pathway Steroid Hormone Mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To Lipid Cellular Response To Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Response To Lipid Cellular Response To Organic Cyclic Compound Anatomical Structure Development Response To Hormone System Development
Tagcloud ?		1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?