NR1I2 and FGR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NR1I2	FGR
Gene Name		nuclear receptor subfamily 1, group I, member 2	FGR proto-oncogene, Src family tyrosine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Gene Expression Intracellular Receptor Signaling Pathway Exogenous Drug Catabolic Process Xenobiotic Transport Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Drug Export	Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Cytokine Secretion Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Cellular Response To Peptide Hormone Stimulus
Pathways			Platelet homeostasis Platelet sensitization by LDL Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System
Drugs		Vitamin E Erlotinib Estradiol Ethinyl Estradiol Rifampin Rifaximin Paclitaxel Hyperforin SR12813 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Rilpivirine
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ACTN2 ATP6AP1 CHMP1A DYRK2 EIF3I FGR MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBR5	22 interactors: ARRB1 CBL CCR3 CSK DAB2 DOK1 ERBB2 FASLG HCLS1 IKBKG INPP5D KHDRBS1 NR1I2 PTK2 SLAMF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ
Entrez ID		8856	2268
HPRD ID		04346	01288
Ensembl ID		ENSG00000144852	ENSG00000000938
Uniprot IDs		F1D8P9 O75469	P09769 P78453
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Regulation Of Metabolic Process Cell Communication Cellular Response To Hormone Stimulus Positive Regulation Of Metabolic Process Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Signal Transduction Response To Organic Substance Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Stimulus Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation RNA Metabolic Process Regulation Of Signal Transduction Cell Differentiation Regulation Of Cellular Process Response To Steroid Hormone Negative Regulation Of Cellular Metabolic Process Regulation Of Carbohydrate Metabolic Process Developmental Process Involved In Reproduction Regulation Of Signaling Gland Development Reproductive Structure Development Reproductive System Development In Utero Embryonic Development Mammary Gland Development Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated	Signaling Cell Communication Positive Regulation Of Signal Transduction Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Response To Stimulus Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Endocytosis Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Organic Substance Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of Tissue Remodeling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Intracellular Transport Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transport Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Bone Resorption Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl	colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Difference) ?		1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl	colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Intersection) ?