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CFLAR and PSEN2
Number of citations of the paper that reports this interaction (PubMedID
9990034
)
53
Data Source:
HPRD
(in vitro, in vivo)
CFLAR
PSEN2
Description
CASP8 and FADD like apoptosis regulator
presenilin 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Ripoptosome
Golgi Membrane
Kinetochore
Nuclear Inner Membrane
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Plasma Membrane
Synaptic Vesicle
Membrane
Nuclear Membrane
Protein-containing Complex
Presynaptic Membrane
Gamma-secretase Complex
Synaptic Membrane
Molecular Function
Protease Binding
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Protein Binding
Enzyme Activator Activity
Cysteine-type Peptidase Activity
Protein-containing Complex Binding
Protein Binding
Peptidase Activity
Hydrolase Activity
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Biological Process
Response To Hypoxia
Proteolysis
Apoptotic Process
Skeletal Muscle Tissue Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Skeletal Muscle Atrophy
Regulation Of Skeletal Muscle Satellite Cell Proliferation
Skeletal Myofibril Assembly
Macrophage Differentiation
Cellular Response To Insulin Stimulus
Response To Testosterone
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Skeletal Muscle Tissue Regeneration
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Necroptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Dexamethasone Stimulus
Cellular Response To Nitric Oxide
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Negative Regulation Of Myoblast Fusion
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Extracellular Matrix Organization
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Hepatocyte Apoptotic Process
Negative Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Hepatocyte Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Response To Hypoxia
Proteolysis
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Protein Processing
Amyloid-beta Formation
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Calcium Ion Homeostasis
Regulation Of Calcium Import Into The Mitochondrion
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways
TRAIL signaling
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
Drugs
Diseases
Alzheimer's disease (AD)
GWAS
Appendicular lean mass (
33097823
)
Rheumatoid arthritis (
24390342
30423114
)
Triptolide cytotoxicity (
26121980
)
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Interacting Genes
34 interacting genes:
BCL2L1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CUL1
DAXX
DEDD
DEDD2
FADD
IKBKB
MAP2K4
MAP2K7
MEX3B
NEURL3
NFKB1
PSEN2
RAF1
RBX1
RIPK1
RIPK2
RLIM
RNF8
SKP1
SKP2
SMAD3
SPATS1
TNFRSF10B
TRAF1
TRAF2
TRIM31
USP8
61 interacting genes:
AAMP
ACTG1
AP1G1
APH1A
APH1B
APP
AURKA
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HLA-DMB
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OGA
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
Entrez ID
8837
5664
HPRD ID
04671
02860
Ensembl ID
ENSG00000003402
ENSG00000143801
Uniprot IDs
A0A024R3Y4
A0A336TY74
B4E361
E9PAP3
O15519
Q59F61
P49810
PDB IDs
2N5R
3H11
3H13
6M6O
7DEE
7LXC
8YBX
8YD7
8YD8
8YM4
8YM5
8YM6
8YNI
8YNK
8YNL
8YNM
8YNN
7Y5X
7Y5Z
Enriched GO Terms of Interacting Partners
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Apoptotic Process
Cell Death
Programmed Cell Death
Apoptotic Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Extrinsic Apoptotic Signaling Pathway
MAPK Cascade
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway
Signal Transduction
Protein Metabolic Process
JNK Cascade
Cysteine-type Endopeptidase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Ripoptosome
Intracellular Signaling Cassette
Positive Regulation Of Neuron Apoptotic Process
Proteolysis
Death-inducing Signaling Complex
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Execution Phase Of Apoptosis
Response To Stress
Cytosol
Protein Modification Process
Post-translational Protein Modification
Response To External Biotic Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Staurosporine
Death Effector Domain Binding
Protein Polyubiquitination
Cysteine-type Peptidase Activity
Regulation Of Signal Transduction
Death Receptor Binding
T Cell Activation
Regulation Of Intracellular Signal Transduction
Protein Maturation
Positive Regulation Of Protein Metabolic Process
Regulation Of Signaling
Regulation Of Cytokine Production
Cytosol
Notch Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Gamma-secretase Complex
Cytoplasm
Protein Processing
Notch Receptor Processing
Amyloid-beta Formation
Regulation Of Apoptotic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Regulation Of Programmed Cell Death
Cysteine-type Endopeptidase Activity
Membrane Protein Intracellular Domain Proteolysis
Protein Maturation
Cellular Response To Staurosporine
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Cysteine-type Peptidase Activity
Pyroptotic Inflammatory Response
Luteolysis
Endopeptidase Activator Activity
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Organelle Assembly
Death-inducing Signaling Complex
Amyloid Precursor Protein Metabolic Process
Amyloid-beta Metabolic Process
Execution Phase Of Apoptosis
Golgi Membrane
Proteolysis
Positive Regulation Of Apoptotic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Programmed Cell Death
Signal Transduction
Regulation Of Signal Transduction
Membrane Protein Proteolysis
Regulation Of Autophagy
Positive Regulation Of Proteolysis
Cellular Response To Alkaloid
Organelle Organization
Angiogenesis
Negative Regulation Of Programmed Cell Death
Ovulation Cycle Process
Regulation Of Protein Metabolic Process
Regulation Of Smooth Muscle Cell Differentiation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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