CFLAR and SPATS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CFLAR	SPATS1
Description		CASP8 and FADD like apoptosis regulator	spermatogenesis associated serine rich 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding	Protein Binding
	Biological Process	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TRAIL signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)	Itch intensity from mosquito bite adjusted by bite size ( 28199695)
Interacting Genes		34 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CUL1 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 MEX3B NEURL3 NFKB1 PSEN2 RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8	9 interacting genes: CFLAR CTNNA3 GPHN KCTD9 MISP SPG7 TRIM55 TRIM63 ZIC1
Entrez ID		8837	221409
HPRD ID		04671	10248
Ensembl ID		ENSG00000003402	ENSG00000249481
Uniprot IDs		A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61	Q496A3
PDB IDs		2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production	Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Muscle Atrophy Glycine Receptor Clustering Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity M-AAA Complex Microtubule-based Process Skeletal Myofibril Assembly Nitrate Reductase Activity Establishment Of Synaptic Specificity At Neuromuscular Junction Cytoskeleton Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
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