CFLAR and CASP10

Number of citations of the paper that reports this interaction (PMID 9208847)
48

Data Source:
HPRD (in vitro, in vivo)

		CFLAR	CASP10
Gene Name		CASP8 and FADD-like apoptosis regulator	caspase 10, apoptosis-related cysteine peptidase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Ripoptosome	Cytoplasm Cytosol Plasma Membrane CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Protein Complex Binding Death Effector Domain Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Development Skeletal Muscle Atrophy Regulation Of Satellite Cell Proliferation Skeletal Myofibril Assembly Viral Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Apoptotic Signaling Pathway
Pathways		Death Receptor Signalling TRAIL signaling Programmed Cell Death Extrinsic Pathway	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAIL signaling Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 NFKB1 PSEN2 RAF1 RIPK1 RIPK2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2	30 interactors: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		8837	843
HPRD ID		04671	03458
Ensembl ID		ENSG00000003402	ENSG00000003400
Uniprot IDs		B4E361 E9PAP3 O15519	Q92851
PDB IDs		3H11 3H13
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Processing Activation Of Innate Immune Response Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Signal Transduction Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Signal Transduction Regulation Of Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Endopeptidase Activity Signaling Cell Communication Positive Regulation Of Peptidase Activity Regulation Of Innate Immune Response Regulation Of Endopeptidase Activity Immune Response Regulation Of Peptidase Activity Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process	Apoptotic Process Programmed Cell Death Cell Death Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Execution Phase Of Apoptosis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Protein Processing Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Apoptotic Process Intracellular Signal Transduction Proteolysis Regulation Of Necroptotic Process Positive Regulation Of Neuron Apoptotic Process Neuron Death Regulation Of Cellular Protein Metabolic Process Hepatocyte Apoptotic Process Signaling Positive Regulation Of Neuron Death
Tagcloud ?		als2cr11 als2cr12 ancestry bcac casp8 comprising consortium custom dense european exclusions genotyped genotyping gwas icogs imputed intronic missing participating replicated rs1830298 rs36043647 rs59278883 rs7558475 snps spanning telomeric typed yielding	arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Difference) ?		als2cr11 als2cr12 ancestry bcac casp8 comprising consortium custom dense european exclusions genotyped genotyping gwas icogs imputed intronic missing participating replicated rs1830298 rs36043647 rs59278883 rs7558475 snps spanning telomeric typed yielding	arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Intersection) ?