CFLAR and FADD

Number of citations of the paper that reports this interaction (PubMedID 36801923)
90

Data Source:
BioGRID (genetic interference)
HPRD (two hybrid, in vivo)

		CFLAR	FADD
Description		CASP8 and FADD like apoptosis regulator	Fas associated via death domain
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GO Annotations	Cellular Component	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Ripoptosome	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Body Ripoptosome
	Molecular Function	Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Cysteine-type Peptidase Activity Protein-containing Complex Binding	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Tumor Necrosis Factor Receptor Superfamily Binding Receptor Serine/threonine Kinase Binding Signaling Adaptor Activity Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Caspase Binding
	Biological Process	Response To Hypoxia Proteolysis Apoptotic Process Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Macrophage Differentiation Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Skeletal Muscle Tissue Regeneration Positive Regulation Of Neuron Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Positive Regulation Of Cytokine Production Kidney Development Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Positive Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Response To Cocaine Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Lymph Node Development Spleen Development Thymus Development Positive Regulation Of Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Death-inducing Signaling Complex Assembly Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Necroptotic Signaling Pathway Defense Response To Other Organism Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TRAIL signaling	Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Regulation of necroptotic cell death Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Rheumatoid arthritis ( 24390342 30423114) Triptolide cytotoxicity ( 26121980)	Diverticular disease ( 30177863)
Interacting Genes		34 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CUL1 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 MEX3B NEURL3 NFKB1 PSEN2 RAF1 RBX1 RIPK1 RIPK2 RLIM RNF8 SKP1 SKP2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 TRIM31 USP8	57 interacting genes: ABCA1 ANK3 ATG5 BTG1 CASP10 CASP8 CASP8AP2 CDC20 CDH1 CFLAR CSNK1A1 DAP3 DAPK1 DDIT4L DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 NUTM2F PARK7 PEA15 PIDD1 PIN1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RNF4 RYBP SDCBP STAT1 STUB1 TAB1 TCEA2 TNFRSF10A TNFRSF10B TRADD TRAF2 TRAF6 TRIM21 UBE2I XPO5 ZCCHC12 ZMYM5
Entrez ID		8837	8772
HPRD ID		04671	03909
Ensembl ID		ENSG00000003402	ENSG00000168040
Uniprot IDs		A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61	Q13158
PDB IDs		2N5R 3H11 3H13 6M6O 7DEE 7LXC 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN	1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9 6ACI 7LXC 8YBX 8YD7 8YD8 8YNI
Enriched GO Terms of Interacting Partners?		Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway Signal Transduction Protein Metabolic Process JNK Cascade Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Ripoptosome Intracellular Signaling Cassette Positive Regulation Of Neuron Apoptotic Process Proteolysis Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Execution Phase Of Apoptosis Response To Stress Cytosol Protein Modification Process Post-translational Protein Modification Response To External Biotic Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Staurosporine Death Effector Domain Binding Protein Polyubiquitination Cysteine-type Peptidase Activity Regulation Of Signal Transduction Death Receptor Binding T Cell Activation Regulation Of Intracellular Signal Transduction Protein Maturation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cytokine Production	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Death Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Apoptotic Process Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Programmed Cell Death Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasm Canonical NF-kappaB Signal Transduction Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Ripoptosome Regulation Of Protein Modification Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intracellular Signaling Cassette TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Fas Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Primary Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Phosphorylation Death Effector Domain Binding Positive Regulation Of Phosphorylation
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