KYAT1 and VAC14

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid)

		KYAT1	VAC14
Description		kynurenine aminotransferase 1	VAC14 component of PIKFYVE complex
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome
	Molecular Function	Protein Binding Transaminase Activity Kynurenine-oxoglutarate Transaminase Activity Transferase Activity Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity Glutamine-phenylpyruvate Transaminase Activity Cysteine-S-conjugate Beta-lyase Activity	Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Response To Bacterium Kynurenine Metabolic Process L-kynurenine Catabolic Process	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Tryptophan catabolism Phenylalanine metabolism Glutamate and glutamine metabolism	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs		Pyridoxal phosphate Pyridoxamine-5'-Phosphate D-Phenylalanine N(6)-(pyridoxal phosphate)-L-lysine Indoleacetic acid
Diseases
GWAS			Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		5 interacting genes: APP TRIM55 TRIM63 TRIP13 VAC14	107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34
Entrez ID		883	55697
HPRD ID		02769	07660
Ensembl ID		ENSG00000171097	ENSG00000103043
Uniprot IDs		A0A494C066 A8K563 B7Z4W5 Q16773	Q08AM6
PDB IDs		1W7L 1W7M 1W7N 3FVS 3FVU 3FVX 4WLH 4WLJ 4WP0	7K1Y
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Response To Interleukin-1 Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Receptor Internalization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction PAS Complex Regulation Of Non-canonical NF-kappaB Signal Transduction Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Defense Response To Symbiont Defense Response To Other Organism Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Identical Protein Binding Meiotic Recombination Checkpoint Signaling Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Signal Transduction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Developmental Maturation Early Endosome Membrane Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Skeletal Muscle Atrophy Regulation Of Spontaneous Synaptic Transmission	Protein Binding Intermediate Filament
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