NRP1 and TGFBR2

Number of citations of the paper that reports this interaction (PMID 21186301)
14

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NRP1	TGFBR2
Gene Name		neuropilin 1	transforming growth factor, beta receptor II (70/80kDa)
Image
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Sorting Endosome	Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding	Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Angiogenesis Patterning Of Blood Vessels Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration VEGF-activated Neuropilin Signaling Pathway Otic Placode Formation Negative Regulation Of Neuron Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Ganglion Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Blood Vessel Development Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Activation Of Protein Kinase Activity Embryonic Hemopoiesis Wound Healing Regulation Of Cell Proliferation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Palate Development Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Response To Cholesterol Lens Fiber Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Signal transduction by L1 CHL1 interactions Axon guidance Semaphorin interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Neurophilin interactions with VEGF and VEGFR L1CAM interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs			Glycerol
Diseases
GWAS		Schizophrenia ( 21682944) Tetralogy of Fallot ( 23297363)	Breast cancer ( 23535729) Migraine ( 22683712) Tonometry ( 17903302)
Protein-Protein Interactions		22 interactors: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB	44 interactors: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CBL CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX EIF3I ENG GOPC KCNK18 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TCTEX1D4 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TSSK1B ZFYVE9
Entrez ID		8829	7048
HPRD ID		03642	01823
Ensembl ID		ENSG00000099250	ENSG00000163513
Uniprot IDs		A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9	A3QNQ0 D2JYI1 P37173
PDB IDs		1KEX 2QQI 2QQM 2QQN 3I97 4DEQ	1KTZ 1M9Z 1PLO 2PJY 3KFD
Enriched GO Terms of Interacting Partners?		Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Locomotion Regulation Of Epithelial Cell Migration Tissue Morphogenesis Regulation Of Locomotion Blood Vessel Development Vasculature Development Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Proliferation Tissue Development Regulation Of Cell Motility Angiogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Movement Morphogenesis Of An Epithelium Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Ameboidal-type Cell Migration Blood Vessel Morphogenesis Regulation Of Epithelial Cell Proliferation Cell Migration Embryo Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Cell Motility Positive Regulation Of Cell Division Positive Regulation Of Cell Migration System Development Positive Regulation Of Cell Motility Positive Regulation Of Angiogenesis Positive Regulation Of Locomotion Regulation Of Chemotaxis Organ Development Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endothelial Cell Proliferation Cell Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Regulation Of Behavior	Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Tube Development Response To Wounding Regulation Of Cell Death Signaling Positive Regulation Of Phosphorylation Regulation Of Cell Differentiation Cellular Response To Stimulus Signal Transduction Cell Communication Response To Stress Regulation Of Gene Expression Regulation Of Apoptotic Process Tissue Morphogenesis Anatomical Structure Morphogenesis
Tagcloud ?		c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Difference) ?		c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Intersection) ?