NRP1 and SEMA3C

Number of citations of the paper that reports this interaction (PMID 9331348)
85

Data Source:
HPRD (in vivo)

		NRP1	SEMA3C
Gene Name		neuropilin 1	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Sorting Endosome	Extracellular Space Membrane Extracellular Vesicular Exosome
	Molecular Function	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding	Receptor Activity Semaphorin Receptor Binding
	Biological Process	Angiogenesis Patterning Of Blood Vessels Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration VEGF-activated Neuropilin Signaling Pathway Otic Placode Formation Negative Regulation Of Neuron Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Ganglion Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Neural Crest Cell Migration Somitogenesis Blood Vessel Remodeling Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Pulmonary Myocardium Development Immune Response Axon Guidance Post-embryonic Development Neural Tube Development Response To Drug Limb Bud Formation Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
Pathways		Signal transduction by L1 CHL1 interactions Axon guidance Semaphorin interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Neurophilin interactions with VEGF and VEGFR L1CAM interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Schizophrenia ( 21682944) Tetralogy of Fallot ( 23297363)	Bilirubin levels ( 19414484)
Protein-Protein Interactions		22 interactors: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB	2 interactors: NRP1 NRP2
Entrez ID		8829	10512
HPRD ID		03642	04034
Ensembl ID		ENSG00000099250	ENSG00000075223
Uniprot IDs		A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9	B4E2I9 F5H1Z7 Q99985
PDB IDs		1KEX 2QQI 2QQM 2QQN 3I97 4DEQ
Enriched GO Terms of Interacting Partners?		Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Locomotion Regulation Of Epithelial Cell Migration Tissue Morphogenesis Regulation Of Locomotion Blood Vessel Development Vasculature Development Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Proliferation Tissue Development Regulation Of Cell Motility Angiogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Movement Morphogenesis Of An Epithelium Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Ameboidal-type Cell Migration Blood Vessel Morphogenesis Regulation Of Epithelial Cell Proliferation Cell Migration Embryo Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Cell Motility Positive Regulation Of Cell Division Positive Regulation Of Cell Migration System Development Positive Regulation Of Cell Motility Positive Regulation Of Angiogenesis Positive Regulation Of Locomotion Regulation Of Chemotaxis Organ Development Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endothelial Cell Proliferation Cell Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Regulation Of Behavior	Vestibulocochlear Nerve Structural Organization Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Hypothalamus Cell Migration Neural Crest Cell Migration Involved In Autonomic Nervous System Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Hypothalamus Cell Differentiation Axon Extension Involved In Axon Guidance Vestibulocochlear Nerve Development Sympathetic Ganglion Development Facial Nerve Structural Organization Facial Nerve Morphogenesis Cerebral Cortex Tangential Migration Ganglion Development Vascular Endothelial Growth Factor Signaling Pathway Parasympathetic Nervous System Development Anatomical Structure Arrangement Sympathetic Nervous System Development Hypothalamus Development Cellular Response To Vascular Endothelial Growth Factor Stimulus Semaphorin-plexin Signaling Pathway Forebrain Neuron Development Substrate-dependent Cell Migration Axon Extension Autonomic Nervous System Development Neural Crest Cell Migration Cranial Nerve Development Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation Forebrain Neuron Differentiation Neuron Projection Extension Neural Crest Cell Development Forebrain Generation Of Neurons Neural Crest Cell Differentiation Positive Regulation Of Epithelial Cell Migration Developmental Cell Growth Regulation Of Endothelial Cell Proliferation Embryonic Pattern Specification Cerebral Cortex Cell Migration Diencephalon Development Nerve Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Limbic System Development Telencephalon Cell Migration
Tagcloud ?		c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger	allograft ansan c1r ccl2 cd97 chip comparatively corneal cxcl6 endothelial f3 folds g1p3 genocheck hla ifi30 keratocytes korea ltd microarray normalization oligo pig platinum porcine rejection stroma stromal xenotransplantation
Tagcloud (Difference) ?		c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger	allograft ansan c1r ccl2 cd97 chip comparatively corneal cxcl6 endothelial f3 folds g1p3 genocheck hla ifi30 keratocytes korea ltd microarray normalization oligo pig platinum porcine rejection stroma stromal xenotransplantation
Tagcloud (Intersection) ?