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NRP1 and PLXNA1
Number of citations of the paper that reports this interaction (PMID
10520994
)
132
Data Source:
HPRD
(in vitro, in vivo)
NRP1
PLXNA1
Gene Name
neuropilin 1
plexin A1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Semaphorin Receptor Complex
Extracellular Space
Early Endosome
Cytosol
Neurofilament
Plasma Membrane
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Axon
Growth Cone
Cytoplasmic Vesicle
Neuronal Cell Body
Receptor Complex
Sorting Endosome
Semaphorin Receptor Complex
Nucleus
Cytoplasm
Plasma Membrane
Integral Component Of Membrane
Extracellular Vesicular Exosome
Molecular Function
Vascular Endothelial Growth Factor-activated Receptor Activity
Protein Binding
Heparin Binding
Coreceptor Activity
Semaphorin Receptor Activity
Growth Factor Binding
Cytokine Binding
Vascular Endothelial Growth Factor Binding
Metal Ion Binding
Receptor Activity
Semaphorin Receptor Activity
Biological Process
Angiogenesis
Patterning Of Blood Vessels
Neuron Migration
Positive Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Cell Migration Involved In Sprouting Angiogenesis
Signal Transduction
Cell-cell Signaling
Axon Guidance
Axonal Fasciculation
Response To Wounding
Organ Morphogenesis
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Facial Nerve Structural Organization
Trigeminal Nerve Structural Organization
Vestibulocochlear Nerve Structural Organization
Nerve Development
Branchiomotor Neuron Axon Guidance
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Retinal Ganglion Cell Axon Guidance
Cellular Response To Hepatocyte Growth Factor Stimulus
Endothelial Cell Chemotaxis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Ventral Trunk Neural Crest Cell Migration
VEGF-activated Neuropilin Signaling Pathway
Otic Placode Formation
Negative Regulation Of Neuron Apoptotic Process
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Positive Regulation Of Axon Extension Involved In Axon Guidance
Negative Regulation Of Axon Extension Involved In Axon Guidance
Artery Morphogenesis
Axon Extension Involved In Axon Guidance
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Cytokine Activity
Axonogenesis Involved In Innervation
Regulation Of Vesicle-mediated Transport
Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
Angiogenesis Involved In Coronary Vascular Morphogenesis
Coronary Artery Morphogenesis
Retina Vasculature Morphogenesis In Camera-type Eye
Renal Artery Morphogenesis
Sympathetic Ganglion Development
Trigeminal Ganglion Development
Ganglion Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Semaphorin-plexin Signaling Pathway
Commissural Neuron Axon Guidance
Regulation Of Retinal Ganglion Cell Axon Guidance
Endothelial Tip Cell Fate Specification
Sensory Neuron Axon Guidance
Sympathetic Neuron Projection Extension
Sympathetic Neuron Projection Guidance
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Toxin Transport
Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance
Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Positive Regulation Of Retinal Ganglion Cell Axon Guidance
VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance
Protein Localization To Early Endosome
Facioacoustic Ganglion Development
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Multicellular Organismal Development
Axon Guidance
Regulation Of Smooth Muscle Cell Migration
Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
Semaphorin-plexin Signaling Pathway
Pathways
Signal transduction by L1
CHL1 interactions
Axon guidance
Semaphorin interactions
Signaling by VEGF
Sema3A PAK dependent Axon repulsion
Neurophilin interactions with VEGF and VEGFR
L1CAM interactions
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Axon guidance
Semaphorin interactions
Other semaphorin interactions
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Drugs
Diseases
GWAS
Schizophrenia (
21682944
)
Tetralogy of Fallot (
23297363
)
MRI atrophy measures (
21116278
)
Protein-Protein Interactions
22 interactors:
FGF1
FGF2
FGF4
FGF7
FGFR1
FLT1
GIPC1
KDR
L1CAM
NRP2
PGF
PLXNA1
RPL27
SEMA3A
SEMA3B
SEMA3C
SEMA3F
TGFBR1
TGFBR2
TGFBR3
VEGFA
VEGFB
7 interactors:
AKT1
FES
NRP1
PLXNB1
RHOD
RND1
SEMA6D
Entrez ID
8829
5361
HPRD ID
03642
11868
Ensembl ID
ENSG00000099250
ENSG00000114554
Uniprot IDs
A8K9V7
O14786
Q59F20
Q68DN3
Q6AWA9
Q9UIW2
PDB IDs
1KEX
2QQI
2QQM
2QQN
3I97
4DEQ
Enriched GO Terms of Interacting Partners
?
Morphogenesis Of A Branching Epithelium
Morphogenesis Of A Branching Structure
Regulation Of Cellular Component Movement
Anatomical Structure Morphogenesis
Locomotion
Regulation Of Epithelial Cell Migration
Tissue Morphogenesis
Regulation Of Locomotion
Blood Vessel Development
Vasculature Development
Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Cell Migration
Chemotaxis
Positive Regulation Of Cell Proliferation
Tissue Development
Regulation Of Cell Motility
Angiogenesis
Cardiovascular System Development
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cellular Component Movement
Morphogenesis Of An Epithelium
Positive Regulation Of Epithelial Cell Proliferation
Cell Surface Receptor Signaling Pathway
Ameboidal-type Cell Migration
Blood Vessel Morphogenesis
Regulation Of Epithelial Cell Proliferation
Cell Migration
Embryo Development
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Cell Proliferation
Movement Of Cell Or Subcellular Component
Cell Motility
Positive Regulation Of Cell Division
Positive Regulation Of Cell Migration
System Development
Positive Regulation Of Cell Motility
Positive Regulation Of Angiogenesis
Positive Regulation Of Locomotion
Regulation Of Chemotaxis
Organ Development
Organ Morphogenesis
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Endothelial Cell Proliferation
Cell Development
Multicellular Organismal Development
Cell Differentiation
Anatomical Structure Development
Regulation Of Behavior
Cell Projection Organization
Axon Guidance
Axonogenesis
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Regulation Of Cell Adhesion
Regulation Of Cell Motility
Neuron Projection Morphogenesis
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Cell Morphogenesis Involved In Differentiation
Generation Of Neurons
Neurogenesis
Neuron Projection Development
Cell Projection Morphogenesis
Positive Regulation Of Cell Migration
Cell Part Morphogenesis
Positive Regulation Of Cell Motility
Cell Development
Response To External Stimulus
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Neuron Development
Regulation Of Neuron Projection Development
Cell Morphogenesis
Negative Regulation Of Osteoblast Proliferation
Neuron Differentiation
Nervous System Development
Regulation Of Cell Projection Organization
Locomotion
Regulation Of Neuron Differentiation
Regulation Of Cell Migration
Movement Of Cell Or Subcellular Component
Positive Regulation Of Smooth Muscle Cell Migration
Regulation Of Osteoblast Proliferation
Regulation Of Neurogenesis
Positive Regulation Of Neuron Projection Development
Semaphorin-plexin Signaling Pathway
Regulation Of Cell Development
Positive Regulation Of Cell Differentiation
Positive Regulation Of Cell Projection Organization
Cell Differentiation
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Smooth Muscle Cell Migration
Regulation Of Cellular Component Organization
Regulation Of Organelle Organization
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Endothelial Cell Proliferation
Tagcloud
?
c57bl
cd25
cd28
cd3
cd4
cd8
ctla
cytometry
distinguishing
draining
ebi3
foxp3
helios
herein
neuropilin
nodes
pdlns
peripherally
proportion
ptreg
reliable
seems
spleen
stimulating
thymic
thymus
treg
ttreg
younger
Tagcloud (Difference)
?
c57bl
cd25
cd28
cd3
cd4
cd8
ctla
cytometry
distinguishing
draining
ebi3
foxp3
helios
herein
neuropilin
nodes
pdlns
peripherally
proportion
ptreg
reliable
seems
spleen
stimulating
thymic
thymus
treg
ttreg
younger
Tagcloud (Intersection)
?