NRP1 and TGFBR1

Number of citations of the paper that reports this interaction (PMID 21186301)
14

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NRP1	TGFBR1
Gene Name		neuropilin 1	transforming growth factor, beta receptor 1
Image
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Sorting Endosome	Cell Endosome Plasma Membrane Tight Junction Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Receptor Signaling Protein Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Growth Factor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding I-SMAD Binding
	Biological Process	Angiogenesis Patterning Of Blood Vessels Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration VEGF-activated Neuropilin Signaling Pathway Otic Placode Formation Negative Regulation Of Neuron Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Ganglion Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Activation Of MAPKK Activity Skeletal System Development Angiogenesis In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Arrest Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Wound Healing Endothelial Cell Activation Extracellular Structure Organization Regulation Of Protein Binding Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Palate Development Pharyngeal System Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Response To Cholesterol Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signal transduction by L1 CHL1 interactions Axon guidance Semaphorin interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Neurophilin interactions with VEGF and VEGFR L1CAM interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Schizophrenia ( 21682944) Tetralogy of Fallot ( 23297363)	Age-related macular degeneration ( 23455636) Dental caries ( 23064961)
Protein-Protein Interactions		22 interactors: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB	159 interactors: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13 EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 MAP3K7 MYO3A MYOC NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP4 USP45 VEPH1 WDR13 WDR33 WDR61 XIAP ZAK ZFYVE9
Entrez ID		8829	7046
HPRD ID		03642	01822
Ensembl ID		ENSG00000099250	ENSG00000106799
Uniprot IDs		A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9	P36897 Q5T7S2
PDB IDs		1KEX 2QQI 2QQM 2QQN 3I97 4DEQ	1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM
Enriched GO Terms of Interacting Partners?		Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Locomotion Regulation Of Epithelial Cell Migration Tissue Morphogenesis Regulation Of Locomotion Blood Vessel Development Vasculature Development Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Proliferation Tissue Development Regulation Of Cell Motility Angiogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Movement Morphogenesis Of An Epithelium Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Ameboidal-type Cell Migration Blood Vessel Morphogenesis Regulation Of Epithelial Cell Proliferation Cell Migration Embryo Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Cell Motility Positive Regulation Of Cell Division Positive Regulation Of Cell Migration System Development Positive Regulation Of Cell Motility Positive Regulation Of Angiogenesis Positive Regulation Of Locomotion Regulation Of Chemotaxis Organ Development Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endothelial Cell Proliferation Cell Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Regulation Of Behavior	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signal Transduction Response To Transforming Growth Factor Beta Signal Transduction Cell Communication Signaling Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Cellular Response To Stimulus Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Modification Process Regulation Of Signaling Response To Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Organic Substance Protein Phosphorylation Phosphorylation Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Process Signal Transduction By Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Morphogenesis SMAD Protein Complex Assembly Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial To Mesenchymal Transition
Tagcloud ?		c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?