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NRP1 and PGF
Number of citations of the paper that reports this interaction (PubMedID
11986311
)
0
Data Source:
HPRD
(in vitro, in vivo)
NRP1
PGF
Description
neuropilin 1
placental growth factor
Image
GO Annotations
Cellular Component
Semaphorin Receptor Complex
Extracellular Region
Extracellular Space
Cytoplasm
Mitochondrion
Early Endosome
Cytosol
Neurofilament
Plasma Membrane
Focal Adhesion
Membrane
Axon
Cytoplasmic Vesicle
Mitochondrial Membrane
Neuron Projection
Receptor Complex
Postsynaptic Membrane
Sorting Endosome
Glutamatergic Synapse
Extracellular Region
Extracellular Space
Membrane
Molecular Function
Vascular Endothelial Growth Factor Receptor Activity
GTPase Activator Activity
Protein Binding
Heparin Binding
Coreceptor Activity
Semaphorin Receptor Activity
Growth Factor Binding
Protein Kinase Binding
Cytokine Binding
Vascular Endothelial Growth Factor Binding
Metal Ion Binding
Vascular Endothelial Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemoattractant Activity
Receptor Ligand Activity
Biological Process
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Neural Crest Cell Migration
Neuron Migration
Positive Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Cell Migration Involved In Sprouting Angiogenesis
Outflow Tract Septum Morphogenesis
Substrate-dependent Cell Migration, Cell Extension
Signal Transduction
Integrin-mediated Signaling Pathway
Cell-cell Signaling
Nervous System Development
Axon Guidance
Axonal Fasciculation
Heart Development
Motor Neuron Axon Guidance
Response To Wounding
Animal Organ Morphogenesis
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Facial Nerve Structural Organization
Trigeminal Nerve Morphogenesis
Trigeminal Nerve Structural Organization
Vestibulocochlear Nerve Structural Organization
Branchiomotor Neuron Axon Guidance
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Cell Differentiation
Negative Regulation Of Axon Extension
Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Retinal Ganglion Cell Axon Guidance
Regulation Of Cdc42 Protein Signal Transduction
Cellular Response To Hepatocyte Growth Factor Stimulus
Endothelial Cell Chemotaxis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Ventral Trunk Neural Crest Cell Migration
Vascular Endothelial Growth Factor Signaling Pathway
Neuropilin Signaling Pathway
VEGF-activated Neuropilin Signaling Pathway
Positive Regulation Of Phosphorylation
Negative Regulation Of Neuron Apoptotic Process
Blood Vessel Endothelial Cell Migration
Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Symbiont Entry Into Host Cell
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Sympathetic Nervous System Development
Neuron Development
Axon Extension
Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Axon Extension Involved In Axon Guidance
Negative Regulation Of Axon Extension Involved In Axon Guidance
Artery Morphogenesis
Axon Extension Involved In Axon Guidance
Positive Chemotaxis
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Axonogenesis Involved In Innervation
Regulation Of Vesicle-mediated Transport
Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
Angiogenesis Involved In Coronary Vascular Morphogenesis
Coronary Artery Morphogenesis
Retina Vasculature Development In Camera-type Eye
Retina Vasculature Morphogenesis In Camera-type Eye
Renal Artery Morphogenesis
Sympathetic Ganglion Development
Trigeminal Ganglion Development
Positive Regulation Of ERK1 And ERK2 Cascade
Semaphorin-plexin Signaling Pathway
Commissural Neuron Axon Guidance
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Endothelial Tip Cell Fate Specification
Sensory Neuron Axon Guidance
Motor Neuron Migration
Sympathetic Neuron Projection Extension
Sympathetic Neuron Projection Guidance
Postsynapse Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Basal Dendrite Development
Basal Dendrite Arborization
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Protein Localization To Early Endosome
Facioacoustic Ganglion Development
Dorsal Root Ganglion Morphogenesis
Otic Placode Development
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Angiogenesis
Response To Hypoxia
Sprouting Angiogenesis
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Cell Differentiation
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Induction Of Positive Chemotaxis
Positive Regulation Of Cell Division
Positive Regulation Of Mast Cell Chemotaxis
Pathways
Neurophilin interactions with VEGF and VEGFR
Signaling by ROBO receptors
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Signal transduction by L1
CHL1 interactions
Attachment and Entry
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
Drugs
Aflibercept
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Coronary artery disease (
29212778
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol levels (
32203549
)
Migraine (
27322543
)
Reticulocyte count (
32888494
)
Schizophrenia (
21682944
)
Small cell lung carcinoma (
28604730
)
Tetralogy of Fallot (
23297363
)
Type 1 diabetes (
34127860
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Mood instability (
29187730
)
Refractive error (
32231278
)
Serum alkaline phosphatase levels (
33547301
)
Interacting Genes
27 interacting genes:
FGF1
FGF2
FGF4
FGF7
FGFR1
FLT1
GIPC1
KDR
L1CAM
NRP2
PGF
PLXNA1
PLXNB1
RPL27
SEMA3A
SEMA3B
SEMA3C
SEMA3F
SNCA
SNX5
SNX6
TGFBR1
TGFBR2
TGFBR3
USP9X
VEGFA
VEGFB
4 interacting genes:
FLT1
NRP1
NRP2
VEGFA
Entrez ID
8829
5228
HPRD ID
03642
03076
Ensembl ID
ENSG00000099250
ENSG00000119630
Uniprot IDs
A8K9V7
E9PEP6
O14786
Q59F20
Q6X907
G3XA84
P49763
Q53XY6
Q86TW6
PDB IDs
1KEX
2QQI
2QQM
2QQN
3I97
4DEQ
4RN5
5C7G
5IJR
5IYY
5J1X
5JGI
5JGQ
5JHK
5L73
6FMC
6FMF
6TKK
7JJC
7O1N
7P5U
8C5G
8PFE
9EOU
1FZV
1RV6
Enriched GO Terms of Interacting Partners
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Regulation Of Locomotion
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Regulation Of Cell Motility
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Semaphorin-plexin Signaling Pathway
Cell Migration
Enzyme-linked Receptor Protein Signaling Pathway
Heparin Binding
Chemotaxis
Cell Motility
Cell Surface Receptor Signaling Pathway
Locomotion
Vascular Endothelial Growth Factor Signaling Pathway
Tissue Morphogenesis
Positive Regulation Of Cell Division
Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Chemotaxis
Neuropilin Binding
Angiogenesis
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Extracellular Region
Positive Regulation Of Cell Population Proliferation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Semaphorin Receptor Binding
Lung Development
Anatomical Structure Morphogenesis
Regulation Of Cell Division
Positive Regulation Of Vasculature Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Migration
Regulation Of Endothelial Cell Migration
Positive Regulation Of Phosphate Metabolic Process
Chemoattractant Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Response To Growth Factor
Developmental Growth Involved In Morphogenesis
Neuron Projection Guidance
Positive Regulation Of MAPK Cascade
Morphogenesis Of An Epithelium
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Activity
Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cellular Response To Vascular Endothelial Growth Factor Stimulus
VEGF-activated Neuropilin Signaling Pathway
Vestibulocochlear Nerve Structural Organization
Dorsal Root Ganglion Morphogenesis
Sensory Neuron Axon Guidance
Facioacoustic Ganglion Development
Growth Factor Binding
Angiogenesis
Chemotaxis
Ventral Trunk Neural Crest Cell Migration
Locomotion
Regulation Of Epithelial Cell Proliferation
Neuropilin Signaling Pathway
Sympathetic Neuron Projection Guidance
Trigeminal Ganglion Development
Cranial Ganglion Development
Trunk Neural Crest Cell Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Endothelial Cell Proliferation
Trigeminal Nerve Structural Organization
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Sympathetic Neuron Projection Extension
Blood Vessel Morphogenesis
Branchiomotor Neuron Axon Guidance
Positive Regulation Of Cell Migration
Hypothalamus Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Locomotion
Coronary Artery Morphogenesis
Facial Nerve Structural Organization
Sympathetic Ganglion Development
Enzyme-linked Receptor Protein Signaling Pathway
Coronary Vasculature Morphogenesis
Endothelial Cell Chemotaxis
Axon Extension Involved In Axon Guidance
Neuron Migration
Motor Neuron Migration
Heparin Binding
Semaphorin Receptor Activity
Commissural Neuron Axon Guidance
Semaphorin Receptor Complex
Positive Regulation Of Angiogenesis
Tagcloud
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Tagcloud (Intersection)
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