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NRP1 and FGF4
Number of citations of the paper that reports this interaction (PubMedID
15695515
)
0
Data Source:
HPRD
(in vitro)
NRP1
FGF4
Description
neuropilin 1
fibroblast growth factor 4
Image
GO Annotations
Cellular Component
Semaphorin Receptor Complex
Extracellular Region
Extracellular Space
Cytoplasm
Mitochondrion
Early Endosome
Cytosol
Neurofilament
Plasma Membrane
Focal Adhesion
Membrane
Axon
Cytoplasmic Vesicle
Mitochondrial Membrane
Neuron Projection
Receptor Complex
Postsynaptic Membrane
Sorting Endosome
Glutamatergic Synapse
Extracellular Region
Extracellular Space
Cytoplasm
Molecular Function
Vascular Endothelial Growth Factor Receptor Activity
GTPase Activator Activity
Protein Binding
Heparin Binding
Coreceptor Activity
Semaphorin Receptor Activity
Growth Factor Binding
Protein Kinase Binding
Cytokine Binding
Vascular Endothelial Growth Factor Binding
Metal Ion Binding
Fibroblast Growth Factor Receptor Binding
Growth Factor Activity
Heparin Binding
Biological Process
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Neural Crest Cell Migration
Neuron Migration
Positive Regulation Of Endothelial Cell Proliferation
Sprouting Angiogenesis
Cell Migration Involved In Sprouting Angiogenesis
Outflow Tract Septum Morphogenesis
Substrate-dependent Cell Migration, Cell Extension
Signal Transduction
Integrin-mediated Signaling Pathway
Cell-cell Signaling
Nervous System Development
Axon Guidance
Axonal Fasciculation
Heart Development
Motor Neuron Axon Guidance
Response To Wounding
Animal Organ Morphogenesis
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Facial Nerve Structural Organization
Trigeminal Nerve Morphogenesis
Trigeminal Nerve Structural Organization
Vestibulocochlear Nerve Structural Organization
Branchiomotor Neuron Axon Guidance
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Cell Differentiation
Negative Regulation Of Axon Extension
Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Retinal Ganglion Cell Axon Guidance
Regulation Of Cdc42 Protein Signal Transduction
Cellular Response To Hepatocyte Growth Factor Stimulus
Endothelial Cell Chemotaxis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Ventral Trunk Neural Crest Cell Migration
Vascular Endothelial Growth Factor Signaling Pathway
Neuropilin Signaling Pathway
VEGF-activated Neuropilin Signaling Pathway
Positive Regulation Of Phosphorylation
Negative Regulation Of Neuron Apoptotic Process
Blood Vessel Endothelial Cell Migration
Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Symbiont Entry Into Host Cell
Platelet-derived Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Sympathetic Nervous System Development
Neuron Development
Axon Extension
Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Axon Extension Involved In Axon Guidance
Negative Regulation Of Axon Extension Involved In Axon Guidance
Artery Morphogenesis
Axon Extension Involved In Axon Guidance
Positive Chemotaxis
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Axonogenesis Involved In Innervation
Regulation Of Vesicle-mediated Transport
Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
Angiogenesis Involved In Coronary Vascular Morphogenesis
Coronary Artery Morphogenesis
Retina Vasculature Development In Camera-type Eye
Retina Vasculature Morphogenesis In Camera-type Eye
Renal Artery Morphogenesis
Sympathetic Ganglion Development
Trigeminal Ganglion Development
Positive Regulation Of ERK1 And ERK2 Cascade
Semaphorin-plexin Signaling Pathway
Commissural Neuron Axon Guidance
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Endothelial Tip Cell Fate Specification
Sensory Neuron Axon Guidance
Motor Neuron Migration
Sympathetic Neuron Projection Extension
Sympathetic Neuron Projection Guidance
Postsynapse Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Basal Dendrite Development
Basal Dendrite Arborization
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Protein Localization To Early Endosome
Facioacoustic Ganglion Development
Dorsal Root Ganglion Morphogenesis
Otic Placode Development
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Cartilage Condensation
Apoptotic Process
Signal Transduction
Cell-cell Signaling
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Mesenchymal Cell Proliferation
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Stem Cell Population Maintenance
Neurogenesis
Cell Differentiation
Embryonic Limb Morphogenesis
Regulation Of Cell Migration
Somatic Stem Cell Population Maintenance
Embryonic Hindlimb Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Division
Cranial Suture Morphogenesis
Apoptotic Process Involved In Morphogenesis
Chondroblast Differentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Stem Cell Proliferation
Epithelial Cell Apoptotic Process
Cellular Response To Leukemia Inhibitory Factor
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of Stem Cell Proliferation
Pathways
Neurophilin interactions with VEGF and VEGFR
Signaling by ROBO receptors
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Signal transduction by L1
CHL1 interactions
Attachment and Entry
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Specification of the neural plate border
Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Pentosan polysulfate
Heparin
TP-508
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Coronary artery disease (
29212778
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol levels (
32203549
)
Migraine (
27322543
)
Reticulocyte count (
32888494
)
Schizophrenia (
21682944
)
Small cell lung carcinoma (
28604730
)
Tetralogy of Fallot (
23297363
)
Type 1 diabetes (
34127860
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Birth weight (
31043758
)
Breast cancer (
20453838
)
Craniofacial microsomia (
26853712
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Urate levels in overweight individuals (
25811787
)
Interacting Genes
27 interacting genes:
FGF1
FGF2
FGF4
FGF7
FGFR1
FLT1
GIPC1
KDR
L1CAM
NRP2
PGF
PLXNA1
PLXNB1
RPL27
SEMA3A
SEMA3B
SEMA3C
SEMA3F
SNCA
SNX5
SNX6
TGFBR1
TGFBR2
TGFBR3
USP9X
VEGFA
VEGFB
5 interacting genes:
FGFR1
FGFR2
FGFR3
FGFR4
NRP1
Entrez ID
8829
2249
HPRD ID
03642
01294
Ensembl ID
ENSG00000099250
ENSG00000075388
Uniprot IDs
A8K9V7
E9PEP6
O14786
Q59F20
Q6X907
A0A7U3JW12
P08620
PDB IDs
1KEX
2QQI
2QQM
2QQN
3I97
4DEQ
4RN5
5C7G
5IJR
5IYY
5J1X
5JGI
5JGQ
5JHK
5L73
6FMC
6FMF
6TKK
7JJC
7O1N
7P5U
8C5G
8PFE
9EOU
1IJT
Enriched GO Terms of Interacting Partners
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Regulation Of Locomotion
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Regulation Of Cell Motility
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Semaphorin-plexin Signaling Pathway
Cell Migration
Enzyme-linked Receptor Protein Signaling Pathway
Heparin Binding
Chemotaxis
Cell Motility
Cell Surface Receptor Signaling Pathway
Locomotion
Vascular Endothelial Growth Factor Signaling Pathway
Tissue Morphogenesis
Positive Regulation Of Cell Division
Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Chemotaxis
Neuropilin Binding
Angiogenesis
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Extracellular Region
Positive Regulation Of Cell Population Proliferation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Semaphorin Receptor Binding
Lung Development
Anatomical Structure Morphogenesis
Regulation Of Cell Division
Positive Regulation Of Vasculature Development
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Migration
Regulation Of Endothelial Cell Migration
Positive Regulation Of Phosphate Metabolic Process
Chemoattractant Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Response To Growth Factor
Developmental Growth Involved In Morphogenesis
Neuron Projection Guidance
Positive Regulation Of MAPK Cascade
Morphogenesis Of An Epithelium
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Fibroblast Growth Factor Receptor Activity
Fibroblast Growth Factor Binding
Positive Regulation Of Phospholipase Activity
Receptor Complex
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Lipase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of MAPK Cascade
Protein Tyrosine Kinase Activity
Heparin Binding
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development
Positive Regulation Of ERK1 And ERK2 Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of MAPK Cascade
Ventricular Zone Neuroblast Division
Orbitofrontal Cortex Development
Peptidyl-tyrosine Phosphorylation
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Catalytic Activity
Regulation Of Developmental Growth
Forebrain Neuroblast Division
Forebrain Ventricular Zone Progenitor Cell Division
Positive Regulation Of Intracellular Signal Transduction
Biomineral Tissue Development
Lung-associated Mesenchyme Development
Endochondral Bone Growth
Positive Regulation Of Hydrolase Activity
Protein Autophosphorylation
Protein Kinase Activity
Animal Organ Morphogenesis
Branching Involved In Salivary Gland Morphogenesis
Regulation Of Catalytic Activity
Positive Regulation Of Signal Transduction
Morphogenesis Of A Branching Epithelium
Cell-cell Signaling
Regulation Of Growth
Regulation Of Cell Population Proliferation
Morphogenesis Of A Branching Structure
Kinase Activity
Positive Regulation Of Developmental Growth
Signaling
Bone Growth
Neuron Development
Cell Communication
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Tissue Development
Positive Regulation Of Epithelial Cell Proliferation
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Tagcloud (Intersection)
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