NRP1 and RPL27

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NRP1	RPL27
Gene Name		neuropilin 1	ribosomal protein L27
Image
Gene Ontology Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Sorting Endosome	Nucleus Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding	Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Angiogenesis Patterning Of Blood Vessels Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration VEGF-activated Neuropilin Signaling Pathway Otic Placode Formation Negative Regulation Of Neuron Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Ganglion Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Signal transduction by L1 CHL1 interactions Axon guidance Semaphorin interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Neurophilin interactions with VEGF and VEGFR L1CAM interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Schizophrenia ( 21682944) Tetralogy of Fallot ( 23297363)
Protein-Protein Interactions		22 interactors: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB	3 interactors: CHUK EP300 NRP1
Entrez ID		8829	6155
HPRD ID		03642	09602
Ensembl ID		ENSG00000099250	ENSG00000131469
Uniprot IDs		A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9	P61353
PDB IDs		1KEX 2QQI 2QQM 2QQN 3I97 4DEQ	3J3B
Enriched GO Terms of Interacting Partners?		Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Locomotion Regulation Of Epithelial Cell Migration Tissue Morphogenesis Regulation Of Locomotion Blood Vessel Development Vasculature Development Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Proliferation Tissue Development Regulation Of Cell Motility Angiogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Movement Morphogenesis Of An Epithelium Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Ameboidal-type Cell Migration Blood Vessel Morphogenesis Regulation Of Epithelial Cell Proliferation Cell Migration Embryo Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Cell Motility Positive Regulation Of Cell Division Positive Regulation Of Cell Migration System Development Positive Regulation Of Cell Motility Positive Regulation Of Angiogenesis Positive Regulation Of Locomotion Regulation Of Chemotaxis Organ Development Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endothelial Cell Proliferation Cell Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Regulation Of Behavior	Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Segmentation Positive Regulation Of Binding Organ Morphogenesis Epithelium Development Regulation Of Protein Binding Histone H2B Acetylation Protein Localization To Early Endosome VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Cytokine Activity Endothelial Tip Cell Fate Specification Angiogenesis Involved In Coronary Vascular Morphogenesis Otic Placode Formation Renal Artery Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Vestibulocochlear Nerve Structural Organization Negative Regulation Of Cyclin Catabolic Process N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Retinal Ganglion Cell Axon Guidance Regulation Of Cytokine Activity VEGF-activated Neuropilin Signaling Pathway Ganglion Morphogenesis Regulation Of Binding Tissue Development Sensory Neuron Axon Guidance Positive Regulation Of Receptor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Cellular Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Tubulin Deacetylation Regulation Of Retinal Ganglion Cell Axon Guidance Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Blood Vessel Endothelial Cell Fate Specification Positive Regulation Of Cytokine Production Coronary Artery Morphogenesis Trigeminal Nerve Structural Organization Endothelial Cell Fate Specification Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Axonogenesis Involved In Innervation Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Ventral Trunk Neural Crest Cell Migration Hypothalamus Cell Migration Branchiomotor Neuron Axon Guidance Hepatocyte Growth Factor Receptor Signaling Pathway Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance
Tagcloud ?		c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger	bc bcl2l2 bctis breakthrough ccna1 comprehending ctsd deregulated deregulations diseasespecific dlc1 fivefold gabrp gsn her2positive hnepi insignificant itga6 klk5 microdissected ngfb ontological profilebased scbg2a1 scgb1d2 serpinb5 stc2 taxonomy tumoradjacent
Tagcloud (Difference) ?		c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger	bc bcl2l2 bctis breakthrough ccna1 comprehending ctsd deregulated deregulations diseasespecific dlc1 fivefold gabrp gsn her2positive hnepi insignificant itga6 klk5 microdissected ngfb ontological profilebased scbg2a1 scgb1d2 serpinb5 stc2 taxonomy tumoradjacent
Tagcloud (Intersection) ?