CCNK and NECAB2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CCNK	NECAB2
Gene Name		cyclin K	N-terminal EF-hand calcium binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus	Cytoplasm
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein Kinase Binding	Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Cell Division Negative Regulation Of Cell Cycle Arrest
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AES ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 DVL3 EFEMP2 FKBP6 HMG20A KCNRG KRTAP4-12 LZTS2 NDC80 NECAB2 PIN1 POLR2A RBPMS RFX6 RHOXF2 STX11 TSC22D4 UBC USHBP1	53 interactors: AIMP2 BEX2 BYSL C1orf109 CAPN3 CARD9 CCDC146 CCDC151 CCDC153 CCDC33 CCNK CENPO DAXX DFFA DGCR6 DGCR6L EHHADH EIF4E2 FAM161A FXR2 GCC1 GTPBP10 HAUS1 INPP1 ISCU KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 NEK6 NGFRAP1 NIP7 NOC4L PRKAA2 PSMA1 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SSC5D TEX11 TTC25 TTR USP7 VTA1 WDYHV1
Entrez ID		8812	54550
HPRD ID		10352	13263
Ensembl ID			ENSG00000103154
Uniprot IDs		O75909	Q7Z6G3
PDB IDs		2I53
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Heterocycle Metabolic Process Regulation Of Cell Cycle Arrest Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Cell Cycle Cellular Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Gene Expression Negative Regulation Of Signal Transduction PiRNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type I Interferon Production Positive Regulation Of Viral Transcription Regulation Of Protein Ubiquitination	Organelle Organization Cell Cycle Regulation Of Apoptotic Process Apoptotic Process Ribosome Biogenesis Regulation Of Cell Death Programmed Cell Death Regulation Of Protein Metabolic Process Cell Cycle Process Cellular Component Assembly Cell Death Death Chromatin Modification Regulation Of Cellular Protein Metabolic Process Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA Positive Regulation Of JNK Cascade Organelle Assembly Cell-cell Adhesion Involved In Gastrulation Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Apoptotic DNA Fragmentation Nitrogen Fixation Autolysis Chromatin Organization Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Tagcloud ?		affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Difference) ?		affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Intersection) ?