CCNK and FKBP6

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CCNK	FKBP6
Gene Name		cyclin K	FK506 binding protein 6, 36kDa
Image
Gene Ontology Annotations	Cellular Component	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus	Synaptonemal Complex Cytoplasm Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein Kinase Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Hsp90 Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Cell Division Negative Regulation Of Cell Cycle Arrest	Protein Peptidyl-prolyl Isomerization Protein Folding Meiotic Nuclear Division Spermatogenesis Cell Differentiation Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation Chaperone-mediated Protein Folding
Pathways			PIWI-interacting RNA (piRNA) biogenesis Regulatory RNA pathways Meiotic synapsis
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-Protein Interactions		26 interactors: AES ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 DVL3 EFEMP2 FKBP6 HMG20A KCNRG KRTAP4-12 LZTS2 NDC80 NECAB2 PIN1 POLR2A RBPMS RFX6 RHOXF2 STX11 TSC22D4 UBC USHBP1	10 interactors: ACD CCDC36 CCNK CDK5RAP3 GAPDH HSP90AA1 LZTS2 NME7 SUMO1P1 TINF2
Entrez ID		8812	8468
HPRD ID		10352	05326
Ensembl ID			ENSG00000077800
Uniprot IDs		O75909	G3V0I2 O75344 Q7Z4T4
PDB IDs		2I53	3B7X
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Heterocycle Metabolic Process Regulation Of Cell Cycle Arrest Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Cell Cycle Cellular Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Gene Expression Negative Regulation Of Signal Transduction PiRNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type I Interferon Production Positive Regulation Of Viral Transcription Regulation Of Protein Ubiquitination	Telomere Assembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Regulation Of Telomere Maintenance Protein Localization To Chromosome Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Peptidyl-cysteine S-trans-nitrosylation Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Cellular Localization Protein Localization To Organelle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Protein Localization Regulation Of Protein ADP-ribosylation Regulation Of DNA Replication Intracellular Transport Positive Regulation Of DNA Metabolic Process Mitotic Cell Cycle Process Multicellular Organismal Development Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Protein Glycosylation Anatomical Structure Development Mitotic Cell Cycle Peptidyl-cysteine S-nitrosylation Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Protection From Non-homologous End Joining At Telomere Microtubule-based Process Telomere Capping Regulation Of Chromosome Organization Cellular Component Assembly Positive Regulation Of Telomerase Activity Protein Localization Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Developmental Process Protein Ufmylation Spindle Midzone Assembly Regulation Of Protein Glycosylation Regulation Of Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cell Cycle Process Regulation Of Cellular Process Microtubule Severing Negative Regulation Of Glycoprotein Metabolic Process
Tagcloud ?		affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	biogenesis chaperone client duplicated encoded germ homolog hsp90 hsp90alpha isofom kingdoms knockout l1 mammals mislocalization miwi2 nucleotides paralogs pirna pirnas piwi retrotransposon retrotransposons rnas specialized testes transposon unchanged vertebrates
Tagcloud (Difference) ?		affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	biogenesis chaperone client duplicated encoded germ homolog hsp90 hsp90alpha isofom kingdoms knockout l1 mammals mislocalization miwi2 nucleotides paralogs pirna pirnas piwi retrotransposon retrotransposons rnas specialized testes transposon unchanged vertebrates
Tagcloud (Intersection) ?