CCNK and KRTAP8-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCNK	KRTAP8-1
Description		cyclin K	keratin associated protein 8-1
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex	Cytosol Intermediate Filament
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA Damage Response Regulation Of Signal Transduction Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Cell Division Regulation Of Cell Cycle
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	Keratinization
Drugs
Diseases
GWAS		Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Gut microbiota (bacterial taxa) ( 27723756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		54 interacting genes: ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 CYSRT1 DDB1 DDIT4L DVL3 EFEMP2 FAM168B FKBP6 HIVEP1 HMG20A HNRNPH1 HNRNPH2 HOMEZ HOXA1 HSFY1 HSFY2 KCNRG KRTAP13-2 KRTAP19-6 KRTAP19-7 KRTAP4-12 KRTAP6-2 KRTAP8-1 LZTS2 MYCL NDC80 NECAB2 OXER1 PIN1 POLR1C POLR2A POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RBX1 RFX6 RHOXF2 RUNX1 STX11 TLE5 TSC22D4 USHBP1 USP54 ZNF446	78 interacting genes: AANAT AGXT AOC1 ARID5A ATG9A ATXN1L BANP BCAS2 BHLHE40 C11orf16 C1orf94 CAMK2A CCDC17 CCNK CDA CERCAM CIMIP1 CREB5 CRYAB CYSRT1 DAB1 DAZAP2 DMRTB1 DTX2 FAAP20 FAM168A FAM83A FOXD2 FOXP3 GATA2 GCM2 GLIS2 HEY2 HOXC8 HYPK KRTAP12-4 KRTAP19-5 KRTAP26-1 MKRN3 MYOZ3 NKX2-5 NOXA1 P4HA3 PAX3 PITX1 PLSCR4 POGZ POU6F2 PROP1 PRR13 PRR35 PSMA3 RAMAC RBPMS RBPMS2 RNF38 RUSC1 SAXO4 SLC68A1 SMR3A SMUG1 SNRPC TBX18 TEKT3 TIAL1 TLE5 TLX3 TMSB4X TNIP1 TNPO2 TSPYL6 VENTX VEZF1 YTHDF1 ZBTB32 ZC3H10 ZIC1 ZNF34
Entrez ID		8812	337879
HPRD ID		10352	11221
Ensembl ID		ENSG00000090061	ENSG00000183640
Uniprot IDs		O75909	Q8IUC2
PDB IDs		2I53 4CXA 4NST 4UN0 5ACB 5EFQ 6B3E 6CKX 6TD3 7NXJ 7NXK 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8P81 9FMR
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of RNA Metabolic Process DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cyclin-dependent Protein Serine/threonine Kinase Activity Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Identical Protein Binding Regulation Of Primary Metabolic Process Transcription Elongation By RNA Polymerase II Spindle Assembly Involved In Female Meiosis DNA-templated Transcription Elongation Regulation Of Macromolecule Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Chromatin DNA Binding Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Cytoplasmic Stress Granule Protein Homodimerization Activity Identical Protein Binding Regulation Of Gene Expression Nucleoplasm Regulation Of Primary Metabolic Process Cell Fate Commitment Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Muscle Cell Differentiation Pituitary Gland Development Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Cardiac Muscle Cell Fate Commitment Central Nervous System Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Cardiac Cell Development
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