CCNK and HSFY2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCNK	HSFY2
Description		cyclin K	heat shock transcription factor Y-linked 2
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA Damage Response Regulation Of Signal Transduction Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Cell Division Regulation Of Cell Cycle	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		54 interacting genes: ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 CYSRT1 DDB1 DDIT4L DVL3 EFEMP2 FAM168B FKBP6 HIVEP1 HMG20A HNRNPH1 HNRNPH2 HOMEZ HOXA1 HSFY1 HSFY2 KCNRG KRTAP13-2 KRTAP19-6 KRTAP19-7 KRTAP4-12 KRTAP6-2 KRTAP8-1 LZTS2 MYCL NDC80 NECAB2 OXER1 PIN1 POLR1C POLR2A POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RBX1 RFX6 RHOXF2 RUNX1 STX11 TLE5 TSC22D4 USHBP1 USP54 ZNF446	9 interacting genes: ATXN1 BPIFA1 CCNK DTX2 GCM2 NFYC OTUD7B TBX6 TOX2
Entrez ID		8812	159119
HPRD ID		10352	13680
Ensembl ID		ENSG00000090061	ENSG00000169953
Uniprot IDs		O75909	Q96LI6
PDB IDs		2I53 4CXA 4NST 4UN0 5ACB 5EFQ 6B3E 6CKX 6TD3 7NXJ 7NXK 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8P81 9FMR
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of RNA Metabolic Process DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cyclin-dependent Protein Serine/threonine Kinase Activity Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Identical Protein Binding Regulation Of Primary Metabolic Process Transcription Elongation By RNA Polymerase II Spindle Assembly Involved In Female Meiosis DNA-templated Transcription Elongation Regulation Of Macromolecule Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cyclin K-CDK13 Complex Cyclin K-CDK12 Complex Immune Response In Nasopharyngeal-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism DNA-templated Transcription Negative Regulation Of Neuron Maturation Positive Regulation Of Macromolecule Metabolic Process POZ Domain Binding Immune Response In Gut-associated Lymphoid Tissue Nucleus Regulation Of Gene Expression CCAAT-binding Factor Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Gliogenesis Parathyroid Gland Development Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Poly(G) Binding Mesodermal Cell Fate Specification Cyclin/CDK Positive Transcription Elongation Factor Complex Positive Regulation Of TORC2 Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Neuron Maturation Intracellular Phosphate Ion Homeostasis Somite Rostral/caudal Axis Specification RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein K11-linked Deubiquitination Regulation Of Macromolecule Metabolic Process Nuclear Inclusion Body Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Host-mediated Suppression Of Viral Genome Replication Regulation Of TORC2 Signaling
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