CCNK and CDK18

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CCNK	CDK18
Gene Name		cyclin K	cyclin-dependent kinase 18
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus	Cellular_component
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein Kinase Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Cell Division Negative Regulation Of Cell Cycle Arrest	Protein Phosphorylation Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AES ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 DVL3 EFEMP2 FKBP6 HMG20A KCNRG KRTAP4-12 LZTS2 NDC80 NECAB2 PIN1 POLR2A RBPMS RFX6 RHOXF2 STX11 TSC22D4 UBC USHBP1	18 interactors: APP CCDC102B CCDC85B CCNDBP1 CCNK GOLGA2 KIFC3 KRT31 KRT40 LZTS2 MIPOL1 MTUS2 PNMA1 SEC23A TRIM27 TRIM54 TSGA10 YWHAQ
Entrez ID		8812	5129
HPRD ID		10352	01354
Ensembl ID			ENSG00000117266
Uniprot IDs		O75909	Q07002 Q59G02
PDB IDs		2I53
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Heterocycle Metabolic Process Regulation Of Cell Cycle Arrest Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Cell Cycle Cellular Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Gene Expression Negative Regulation Of Signal Transduction PiRNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type I Interferon Production Positive Regulation Of Viral Transcription Regulation Of Protein Ubiquitination
Tagcloud ?		affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	analyze animal ccnd1 ccni ccni2 cdk16 cdk3 cdk4 cdk8 cdk9 cdkis cdkn1a cdkn2a cdks comprehensive confirm cyclin database diabetic diagram islets microarray pancreatic pattern qrt reproduce snps t2d
Tagcloud (Difference) ?		affects associate bulk cdk12 cdk13 ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	analyze animal ccnd1 ccni ccni2 cdk16 cdk3 cdk4 cdk8 cdkis cdkn1a cdkn2a comprehensive confirm cyclin database diabetic diagram islets microarray pancreatic pattern qrt reproduce snps t2d
Tagcloud (Intersection) ?		cdk9 cdks