CCNK and EFEMP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		CCNK	EFEMP2
Gene Name		cyclin K	EGF containing fibulin-like extracellular matrix protein 2
Image
Gene Ontology Annotations	Cellular Component	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus	Extracellular Region Basement Membrane Plasma Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein Kinase Binding	Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity In Utero Embryonic Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Cell Division Negative Regulation Of Cell Cycle Arrest	Signal Transduction Blood Coagulation Extracellular Matrix Organization
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AES ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 DVL3 EFEMP2 FKBP6 HMG20A KCNRG KRTAP4-12 LZTS2 NDC80 NECAB2 PIN1 POLR2A RBPMS RFX6 RHOXF2 STX11 TSC22D4 UBC USHBP1	50 interactors: APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		8812	30008
HPRD ID		10352	05221
Ensembl ID			ENSG00000172638
Uniprot IDs		O75909	O95967 Q9H3D5
PDB IDs		2I53	2KL7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Heterocycle Metabolic Process Regulation Of Cell Cycle Arrest Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Cell Cycle Cellular Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Gene Expression Negative Regulation Of Signal Transduction PiRNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type I Interferon Production Positive Regulation Of Viral Transcription Regulation Of Protein Ubiquitination	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Organ Development Response To Salt Stress Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Death Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process System Development Developmental Process Phospholipid Scrambling Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Heart Contraction Neuron Death Pons Development Anatomical Structure Development Central Nervous System Development Positive Regulation Of Gene Expression Blood Vessel Development Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?		affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		affects associate bulk cdk12 cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?