PEX11B and PEX19

Number of citations of the paper that reports this interaction (PubMedID 10704444)
54

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PEX11B	PEX19
Description		peroxisomal biogenesis factor 11 beta	peroxisomal biogenesis factor 19
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Brush Border Membrane Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding ATPase Binding Protein Carrier Chaperone
	Biological Process	Peroxisome Organization Signal Transduction Peroxisome Fission Regulation Of Peroxisome Size	Protein Folding Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding
Pathways		Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
Interacting Genes		2 interacting genes: HTT PEX19	39 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A DLG4 EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SLC61A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2
Entrez ID		8799	5824
HPRD ID		04844	02610
Ensembl ID		ENSG00000131779	ENSG00000162735
Uniprot IDs		O96011	A0A0S2Z497 P40855
PDB IDs			2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?		Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Aggrephagy Regulation Of Protein Stability Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Positive Regulation Of CAMKK-AMPK Signaling Cascade Negative Regulation Of Lipid Binding Peroxisome Membrane Biogenesis Peroxisome Membrane Class-1 Targeting Sequence Binding Peroxisome Membrane Targeting Sequence Binding Protein Import Into Peroxisome Membrane Membrane Biogenesis Vocal Learning Profilin Binding Observational Learning Protein Targeting To Peroxisome Protein Carrier Chaperone Peroxisome Fission Auditory Behavior Dynactin Binding Protein-containing Complex Mechanosensory Behavior Inclusion Body Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Positive Regulation Of Mitophagy Positive Regulation Of Cation Channel Activity Peroxisome Organization Positive Regulation Of Autophagy Of Mitochondrion Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Ion Transmembrane Transporter Activity Dynein Intermediate Chain Binding Synaptic Vesicle Transport Establishment Of Mitotic Spindle Orientation Positive Regulation Of Cilium Assembly Establishment Of Mitotic Spindle Localization Positive Regulation Of Transporter Activity Beta-tubulin Binding Intracellular Transport Establishment Of Spindle Orientation Vesicle Transport Along Microtubule Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Establishment Of Spindle Localization Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium-mediated Signaling	Peroxisome Organization Peroxisomal Membrane Peroxisomal Membrane Transport Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Intracellular Protein Transmembrane Transport Protein Import Into Peroxisome Matrix, Substrate Release Receptor Recycling Peroxisomal Importomer Complex Protein Transmembrane Transport Long-chain Fatty Acid Import Into Peroxisome Receptor Metabolic Process Protein Import Into Peroxisome Membrane Very Long-chain Fatty Acid Catabolic Process Protein Transmembrane Transporter Activity Establishment Of Protein Localization To Organelle Fatty Acid Oxidation Fatty Acid Catabolic Process Protein Localization To Organelle Lipid Oxidation Cellular Localization Fatty Acyl-CoA Hydrolase Activity Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Cellular Response To Reactive Oxygen Species Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Beta-oxidation Intracellular Transport Protein Monoubiquitination Organelle Organization Sulfur Compound Transmembrane Transporter Activity Amide Transmembrane Transporter Activity Regulation Of Peroxisome Size Peroxisome Membrane Biogenesis Lipid Modification Intracellular Protein Transport Transmembrane Transport Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Response To Reactive Oxygen Species Fatty Acid Transport Protein-containing Complex ATPase-coupled Transmembrane Transporter Activity Protein To Membrane Docking Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport Protein Binding
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