DLK1 and GRN

Number of citations of the paper that reports this interaction (PMID 11846389)
5

Data Source:
HPRD (two hybrid)

		DLK1	GRN
Gene Name		delta-like 1 homolog (Drosophila)	granulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space External Side Of Plasma Membrane Integral Component Of Membrane	Extracellular Space Mitochondrion Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Molecular_function	Cytokine Activity Protein Binding Growth Factor Activity Poly(A) RNA Binding
	Biological Process	Notch Signaling Pathway Multicellular Organismal Development Post-embryonic Development Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Skeletal System Development	Blastocyst Hatching Signal Transduction Embryo Implantation Positive Regulation Of Epithelial Cell Proliferation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Platelet counts ( 22139419) Type 1 diabetes ( 19966805)	Intracranial volume ( 22504418)
Protein-Protein Interactions		3 interactors: GAS1 GRN ZDHHC17	37 interactors: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 TAT TGM2 TOP3B YY1
Entrez ID		8788	2896
HPRD ID		01446	00733
Ensembl ID		ENSG00000185559	ENSG00000030582
Uniprot IDs		P80370 Q969Y6	P28799
PDB IDs			1G26 2JYE 2JYT 2JYU 2JYV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Blastocyst Hatching Outer Ear Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Lipoprotein Transport Magnesium Ion Transport Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Middle Ear Morphogenesis Positive Regulation Of Cell Proliferation Protein Palmitoylation Negative Regulation Of Smoothened Signaling Pathway Dorsal/ventral Neural Tube Patterning	Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Metabolic Process Brain Development Regulation Of Kinase Activity Head Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Pattern Specification Process RNA Biosynthetic Process Regulation Of Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Anatomical Structure Morphogenesis Biosynthetic Process Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Response To Light Stimulus Hindbrain Development Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Phosphorus Metabolic Process Pons Development Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Aromatic Compound Metabolic Process Central Nervous System Neuron Differentiation Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		birthweight chorionic circumference compounded crown cvs fetal genomics grand grb10 homologue igf2 igf2r imprinted imprinting inherited input maternally monoallelic overlook paternal paternally phlda2 placenta pleckstrin rs941576 rump silences villus	arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously
Tagcloud (Difference) ?		birthweight chorionic circumference compounded crown cvs fetal genomics grand grb10 homologue igf2 igf2r imprinted imprinting inherited input maternally monoallelic overlook paternal paternally phlda2 placenta pleckstrin rs941576 rump silences villus	arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously
Tagcloud (Intersection) ?