DLK1

Description		delta like non-canonical Notch ligand 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane
	Molecular Function	Calcium Ion Binding Protein Binding
	Biological Process	Cell Differentiation Negative Regulation Of Notch Signaling Pathway
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body size at age 10 ( 32376654) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Height ( 31562340) Hodgkin's lymphoma ( 34216518) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 29403010 22139419) Refractive error ( 32231278) Type 1 diabetes ( 19966805) Type 2 diabetes ( 32499647)
Interacting Genes		3 interacting genes: GAS1 GRN ZDHHC17
Entrez ID		8788
HPRD ID		01446
Ensembl ID		ENSG00000185559
Uniprot IDs		A8K019 P80370
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Microglial Cell Activation Involved In Immune Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Lysosome Organization Astrocyte Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Aspartic-type Peptidase Activity Trophectodermal Cell Proliferation Positive Regulation Of Protein Folding Positive Regulation Of Trophectodermal Cell Proliferation Protein-cysteine S-myristoyltransferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Respiratory Burst Protein-cysteine S-stearoyltransferase Activity Negative Regulation Of Neutrophil Activation Cerebellar Climbing Fiber To Purkinje Cell Synapse Regulation Of Proteolysis Positive Regulation Of Axon Regeneration Negative Regulation Of Microglial Cell Activation Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Folding Regulation Of Neutrophil Activation Positive Regulation Of Peptidase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway Oxysterol Binding Lysosomal Protein Catabolic Process Locomotory Exploration Behavior Regulation Of Defense Response To Bacterium Regulation Of Lysosome Organization Macrophage Activation Involved In Immune Response Regulation Of Microglial Cell Activation Positive Regulation Of Defense Response To Bacterium Astrocyte Activation Regulation Of Inflammatory Response To Wounding Protein Catabolic Process In The Vacuole Negative Regulation Of Macrophage Activation Regulation Of Respiratory Burst Negative Regulation Of Neuroinflammatory Response Lipoprotein Transport Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Lysosomal Lumen Acidification
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