DLK1 and GAS1

Number of citations of the paper that reports this interaction (PMID 11846389)
5

Data Source:
HPRD (two hybrid)

		DLK1	GAS1
Gene Name		delta-like 1 homolog (Drosophila)	growth arrest-specific 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space External Side Of Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane
	Molecular Function	Molecular_function	Protein Binding
	Biological Process	Notch Signaling Pathway Multicellular Organismal Development Post-embryonic Development Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Skeletal System Development	Positive Regulation Of Mesenchymal Cell Proliferation Cell Cycle Arrest Axon Guidance Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Programmed Cell Death Cerebellum Morphogenesis Dorsal/ventral Neural Tube Patterning Negative Regulation Of Cell Growth Cellular Response To Vascular Endothelial Growth Factor Stimulus Outer Ear Morphogenesis Middle Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Camera-type Eye Development Cell Fate Commitment Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Developmental Growth Eye Morphogenesis Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Palate Development Regulation Of ER To Golgi Vesicle-mediated Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Hedgehog 'on' state Signaling by Hedgehog Ligand-receptor interactions
Drugs
Diseases
GWAS		Platelet counts ( 22139419) Type 1 diabetes ( 19966805)	Insulin resistance/response ( 21901158)
Protein-Protein Interactions		3 interactors: GAS1 GRN ZDHHC17	3 interactors: BIRC2 DLK1 SHH
Entrez ID		8788	2619
HPRD ID		01446	00747
Ensembl ID		ENSG00000185559	ENSG00000180447
Uniprot IDs		P80370 Q969Y6	P54826
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Blastocyst Hatching Outer Ear Morphogenesis Regulation Of ER To Golgi Vesicle-mediated Transport Lipoprotein Transport Magnesium Ion Transport Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Middle Ear Morphogenesis Positive Regulation Of Cell Proliferation Protein Palmitoylation Negative Regulation Of Smoothened Signaling Pathway Dorsal/ventral Neural Tube Patterning	Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Sclerotome Development Multicellular Structure Septum Development Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Embryonic Skeletal System Development Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Right Lung Development Primary Prostatic Bud Elongation Intein-mediated Protein Splicing Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Polarity Specification Of Anterior/posterior Axis Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Left Lung Development Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Monoubiquitination Positive Regulation Of Immature T Cell Proliferation In Thymus Cell Proliferation In Hindbrain Positive Regulation Of Smooth Muscle Cell Differentiation Prostate Epithelial Cord Elongation Specification Of Axis Polarity Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Hh Target Transcription Factor Activity Negative Regulation Of Cholesterol Efflux Negative Regulation Of Proteolysis Positive Regulation Of Immature T Cell Proliferation Regulation Of Protein K63-linked Ubiquitination Bud Outgrowth Involved In Lung Branching Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Negative Regulation Of Protein Processing Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Regulation Of Nodal Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Ventral Midline Development Regulation Of Protein Processing Negative Regulation Of Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Lung Development Salivary Gland Cavitation Bergmann Glial Cell Differentiation Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		birthweight chorionic circumference compounded crown cvs fetal genomics grand grb10 homologue igf2 igf2r imprinted imprinting inherited input maternally monoallelic overlook paternal paternally phlda2 placenta pleckstrin rs941576 rump silences villus	acids ankyrin cca1 cca2 cca3 cdna cloning consist copies decrease encoding frame hepatectomy initiation kinetics level mrna nucleotide nucleotides open partial rapid rat reading regenerating repeat sequencing synthesis transient
Tagcloud (Difference) ?		birthweight chorionic circumference compounded crown cvs fetal genomics grand grb10 homologue igf2 igf2r imprinted imprinting inherited input maternally monoallelic overlook paternal paternally phlda2 placenta pleckstrin rs941576 rump silences villus	acids ankyrin cca1 cca2 cca3 cdna cloning consist copies decrease encoding frame hepatectomy initiation kinetics level mrna nucleotide nucleotides open partial rapid rat reading regenerating repeat sequencing synthesis transient
Tagcloud (Intersection) ?