FADD and PEA15

Number of citations of the paper that reports this interaction (PMID 10442631)
31

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		FADD	PEA15
Gene Name		Fas (TNFRSF6)-associated via death domain	phosphoprotein enriched in astrocytes 15
Image
Gene Ontology Annotations	Cellular Component	Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome	Cytoplasm Microtubule Associated Complex
	Molecular Function	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein Complex Binding Tumor Necrosis Factor Receptor Superfamily Binding Death Effector Domain Binding Identical Protein Binding	Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Spleen Development Thymus Development Protein Heterooligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Necroptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	DNA Damage Checkpoint Transport Apoptotic Process Carbohydrate Transport Response To Morphine Negative Regulation Of Glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Regulation by c-FLIP Caspase-8 activation by cleavage Death Receptor Signalling Dimerization of procaspase-8 TRAIL signaling TRIF-mediated TLR3/TLR4 signaling FasL/ CD95L signaling MyD88-independent cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: ABCA1 ANK3 ATG5 CASP10 CASP8 CASP8AP2 CFLAR CSNK1A1 DAP3 DAPK1 DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 PARK7 PEA15 PIDD1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RYBP SPOP STAT1 SUMO1 TAB1 TNFRSF10A TNFRSF10B TRADD TRAF2 TRIM21 XPO5	18 interactors: ABCD4 AK9 AKT1 CAMK2G CASP8 FADD HTRA2 L1CAM LUC7L2 MAPK1 MAPK3 PANK4 PDPK1 PLD1 PLD2 PRKCA RPS6KA3 TERF2IP
Entrez ID		8772	8682
HPRD ID		03909	04579
Ensembl ID		ENSG00000168040	ENSG00000162734
Uniprot IDs		Q13158	B1AKZ3 B1AKZ4 B1AKZ5 Q15121
PDB IDs		1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9	4IZ5 4IZA
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Peptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Zymogen Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Endopeptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Protein Processing Regulation Of Proteolysis Negative Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Activation Of Protein Kinase Activity	Innate Immune Response Defense Response Positive Regulation Of Immune System Process Immune Response Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stress Toll-like Receptor 4 Signaling Pathway Response To Temperature Stimulus Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Epidermal Growth Factor Response To Growth Factor Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Apoptotic Process Neurotrophin Signaling Pathway Programmed Cell Death Cell Activation Toll-like Receptor Signaling Pathway Response To Heat Response To Cytokine Cell Death Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Immune System Process Activation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Labyrinthine Layer Development Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Signaling Pathway Cellular Response To Heat Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Cellular Response To Organic Substance Cellular Response To Mechanical Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Immune Response Platelet Activation
Tagcloud ?		adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit	abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified
Tagcloud (Difference) ?		adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit	abeta app astrocyte astrocytes astroglial clearance clues cortices degraded deposited differently enriched extracellularly milieu offer performing phagocytosed phagocytosis phosphoprotein precise proteomic ps1 quantified surrounding tag tandem understand upregulated verified
Tagcloud (Intersection) ?