FADD and FAS

Number of citations of the paper that reports this interaction (PubMedID 17159907)
40

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FADD	FAS
Description		Fas associated via death domain	Fas cell surface death receptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Body Ripoptosome	Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Exosome
	Molecular Function	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Tumor Necrosis Factor Receptor Superfamily Binding Receptor Serine/threonine Kinase Binding Signaling Adaptor Activity Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Caspase Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Calmodulin Binding Kinase Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Kidney Development Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Positive Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Response To Cocaine Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Lymph Node Development Spleen Development Thymus Development Positive Regulation Of Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Death-inducing Signaling Complex Assembly Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Necroptotic Signaling Pathway Defense Response To Other Organism Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Activation-induced Cell Death Of T Cells Immune Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Stress-activated MAPK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Fas Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Assembly Cellular Response To Mechanical Stimulus Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Regulation of necroptotic cell death Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Defective RIPK1-mediated regulated necrosis	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling
Drugs
Diseases			Esophageal cancer Chronic lymphocytic leukemia (CLL) Hodgkin lymphoma Adult T-cell leukemia
GWAS		Diverticular disease ( 30177863)	Ankylosing spondylitis ( 30946743) Atrioventricular conduction ( 21041692) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Chronic lymphocytic leukemia ( 23770605 24292274 26956414 28165464) Immunoglobulin A ( 20694011) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758)
Interacting Genes		57 interacting genes: ABCA1 ANK3 ATG5 BTG1 CASP10 CASP8 CASP8AP2 CDC20 CDH1 CFLAR CSNK1A1 DAP3 DAPK1 DDIT4L DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 NUTM2F PARK7 PEA15 PIDD1 PIN1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RNF4 RYBP SDCBP STAT1 STUB1 TAB1 TCEA2 TNFRSF10A TNFRSF10B TRADD TRAF2 TRAF6 TRIM21 UBE2I XPO5 ZCCHC12 ZMYM5	50 interacting genes: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX DNAJC5 EEF1A1 EGFR ERG28 EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 TRIP6 UBA7 UBAC1 UBE2I UBQLN1
Entrez ID		8772	355
HPRD ID		03909	00609
Ensembl ID		ENSG00000168040	ENSG00000026103
Uniprot IDs		Q13158	A0A8Q3SIR6 K9J972 P25445 Q59FU8
PDB IDs		1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9 6ACI 7LXC 8YBX 8YD7 8YD8 8YNI	1DDF 2NA7 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Death Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Apoptotic Process Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Programmed Cell Death Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasm Canonical NF-kappaB Signal Transduction Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Ripoptosome Regulation Of Protein Modification Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intracellular Signaling Cassette TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Fas Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Primary Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Phosphorylation Death Effector Domain Binding Positive Regulation Of Phosphorylation	Cell Death Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Death Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Death-inducing Signaling Complex Regulation Of Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cytosol Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Tumor Necrosis Factor Receptor Binding Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Macrophage Differentiation Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Positive Regulation Of Intracellular Signal Transduction Kinase Binding Regulation Of Macrophage Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Transporter Activity Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Response To Mechanical Stimulus Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Protein-macromolecule Adaptor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phospholipase Activator Activity
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