FADD and DDX24

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		FADD	DDX24
Description		Fas associated via death domain	DEAD-box helicase 24
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Body Ripoptosome	Nucleus Nucleolus Cytoplasm Membrane
	Molecular Function	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Tumor Necrosis Factor Receptor Superfamily Binding Receptor Serine/threonine Kinase Binding Signaling Adaptor Activity Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Caspase Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Positive Regulation Of Cytokine Production Kidney Development Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Positive Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Response To Cocaine Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Lymph Node Development Spleen Development Thymus Development Positive Regulation Of Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Death-inducing Signaling Complex Assembly Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Necroptotic Signaling Pathway Defense Response To Other Organism Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	RNA Metabolic Process
Pathways		Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Regulation of necroptotic cell death Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Diverticular disease ( 30177863)	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		57 interacting genes: ABCA1 ANK3 ATG5 BTG1 CASP10 CASP8 CASP8AP2 CDC20 CDH1 CFLAR CSNK1A1 DAP3 DAPK1 DDIT4L DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 NUTM2F PARK7 PEA15 PIDD1 PIN1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RNF4 RYBP SDCBP STAT1 STUB1 TAB1 TCEA2 TNFRSF10A TNFRSF10B TRADD TRAF2 TRAF6 TRIM21 UBE2I XPO5 ZCCHC12 ZMYM5	37 interacting genes: BCS1L BRCA1 CSNK2A1 EIF3E EP300 FADD FILNC1 GIT1 GLRA2 HSP90AB1 HSPA5 IDO1 ITGB3BP LMNA MDM2 MKS1 MRPL4 NRXN2 PAFAH1B3 PIN1 POLA2 PRF1 PTEN PTPN23 RAE1 RNF10 SPACA9 SPTAN1 TERF1 TERF2 TERF2IP TMEM9B TPI1 TRDMT1 UBE2I USP7 VDAC3
Entrez ID		8772	57062
HPRD ID		03909	05860
Ensembl ID		ENSG00000168040	ENSG00000089737
Uniprot IDs		Q13158	Q9GZR7
PDB IDs		1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9 6ACI 7LXC 8YBX 8YD7 8YD8 8YNI
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Death Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Apoptotic Process Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Programmed Cell Death Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasm Canonical NF-kappaB Signal Transduction Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Ripoptosome Regulation Of Protein Modification Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intracellular Signaling Cassette TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Fas Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Primary Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Phosphorylation Death Effector Domain Binding Positive Regulation Of Phosphorylation	RNA-templated DNA Biosynthetic Process Shelterin Complex Cellular Component Assembly Nuclear Body Regulation Of Protein Stability Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Telomere Capping Regulation Of Cellular Component Organization PML Body Regulation Of Telomere Maintenance Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Organelle Organization Protein Localization To Organelle Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Catabolic Process Telomere Maintenance Via Telomerase P53 Binding Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Regulation Of Cell Communication Protein-containing Complex Regulation Of Signaling Regulation Of Organelle Organization Telomeric DNA Binding Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening DNA Biosynthetic Process Nucleoplasm Regulation Of Cell Cycle Telomere Maintenance Receptor Serine/threonine Kinase Binding Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Regulation Of DNA Metabolic Process Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Protection From Non-homologous End Joining At Telomere Negative Regulation Of Small Molecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?