FADD and NOL3

Number of citations of the paper that reports this interaction (PMID 9560245)
36

Data Source:
BioGRID (genetic interference)
HPRD (in vitro, in vivo)

		FADD	NOL3
Gene Name		Fas (TNFRSF6)-associated via death domain	nucleolar protein 3 (apoptosis repressor with CARD domain)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome	Nucleolus Cytoplasm Mitochondrion Cytosol Sarcoplasm
	Molecular Function	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein Complex Binding Tumor Necrosis Factor Receptor Superfamily Binding Death Effector Domain Binding Identical Protein Binding	RNA Binding Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Caspase Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Spleen Development Thymus Development Protein Heterooligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Necroptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Hypoxia MRNA Splice Site Selection RNA Splicing Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Oligomerization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation by c-FLIP Caspase-8 activation by cleavage Death Receptor Signalling Dimerization of procaspase-8 TRAIL signaling TRIF-mediated TLR3/TLR4 signaling FasL/ CD95L signaling MyD88-independent cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: ABCA1 ANK3 ATG5 CASP10 CASP8 CASP8AP2 CFLAR CSNK1A1 DAP3 DAPK1 DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 PARK7 PEA15 PIDD1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RYBP SPOP STAT1 SUMO1 TAB1 TNFRSF10A TNFRSF10B TRADD TRAF2 TRIM21 XPO5	15 interactors: BAX CASP2 CASP8 CSNK2A1 ETNK2 FADD NIF3L1 POT1 SIRPA SRSF9 TERF1 TERF2IP TFPT TINF2 VASP
Entrez ID		8772	8996
HPRD ID		03909	05572
Ensembl ID		ENSG00000168040	ENSG00000140939
Uniprot IDs		Q13158	B4DFL0 O60936 Q5TZN6
PDB IDs		1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Peptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Zymogen Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Endopeptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Protein Processing Regulation Of Proteolysis Negative Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Activation Of Protein Kinase Activity	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Positive Regulation Of Organelle Organization Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Chromosome Organization Regulation Of Cysteine-type Endopeptidase Activity RNA-dependent DNA Replication Negative Regulation Of DNA Metabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Cell Death Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of DNA Replication Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Peptidase Activity Protein Oligomerization Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Assembly Telomere Assembly Regulation Of Lymphocyte Apoptotic Process Regulation Of Cellular Component Organization Protein Processing Cellular Response To Mechanical Stimulus Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Telomerase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Telomere Maintenance Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Macrophage Differentiation Cell Death Activation Of Cysteine-type Endopeptidase Activity Death
Tagcloud ?		adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit	bak1 birc2 birc3 c57bl cgy eosin evident gamma greatest gy hematoxylin irradiated ldr livers mcl1 modified nearly phagocytosis proton protons radiation radical ray rays regimen sections stained strikingly traf3
Tagcloud (Difference) ?		adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit	bak1 birc2 birc3 c57bl cgy eosin evident gamma greatest gy hematoxylin irradiated ldr livers mcl1 modified nearly phagocytosis proton protons radiation radical ray rays regimen sections stained strikingly traf3
Tagcloud (Intersection) ?