FADD and NACA

Number of citations of the paper that reports this interaction (PubMedID 12684039)
0

Data Source:
HPRD (in vivo, in vitro)

		FADD	NACA
Description		Fas associated via death domain	nascent polypeptide associated complex subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Body Ripoptosome	Nucleus Cytoplasm Nascent Polypeptide-associated Complex Extracellular Exosome
	Molecular Function	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Tumor Necrosis Factor Receptor Superfamily Binding Receptor Serine/threonine Kinase Binding Signaling Adaptor Activity Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Caspase Binding	DNA Binding Transcription Coactivator Activity Protein Binding Unfolded Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Kidney Development Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Positive Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Response To Cocaine Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Lymph Node Development Spleen Development Thymus Development Positive Regulation Of Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Death-inducing Signaling Complex Assembly Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Necroptotic Signaling Pathway Defense Response To Other Organism Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Ventricle Development Translation Protein Targeting To Membrane Negative Regulation Of Striated Muscle Cell Apoptotic Process Protein Transport Wound Healing Skeletal Muscle Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Fiber Development Heart Trabecula Morphogenesis Negative Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Regulation of necroptotic cell death Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Diverticular disease ( 30177863)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Asthma ( 31619474) Atrial fibrillation ( 29892015 30061737) Diastolic blood pressure ( 30224653) JT interval ( 29874175) QRS duration ( 30012220)
Interacting Genes		57 interacting genes: ABCA1 ANK3 ATG5 BTG1 CASP10 CASP8 CASP8AP2 CDC20 CDH1 CFLAR CSNK1A1 DAP3 DAPK1 DDIT4L DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 NUTM2F PARK7 PEA15 PIDD1 PIN1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RNF4 RYBP SDCBP STAT1 STUB1 TAB1 TCEA2 TNFRSF10A TNFRSF10B TRADD TRAF2 TRAF6 TRIM21 UBE2I XPO5 ZCCHC12 ZMYM5	17 interacting genes: APLP1 CCDC90B FADD FOS FUNDC2 IGSF21 JUN LRIF1 MDM2 PPP1R18 PTEN SMYD1 SPP1 TBP TXLNA UCHL5 ZHX1
Entrez ID		8772	4666
HPRD ID		03909	03137
Ensembl ID		ENSG00000168040	ENSG00000196531
Uniprot IDs		Q13158	E9PAV3 Q13765
PDB IDs		1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9 6ACI 7LXC 8YBX 8YD7 8YD8 8YNI	3LKX 3MCB 3MCE 7QWQ 7QWR 7QWS 8P2K 9F1B 9F1C 9F1D 9FQ0
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Death Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Apoptotic Process Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Programmed Cell Death Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasm Canonical NF-kappaB Signal Transduction Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Ripoptosome Regulation Of Protein Modification Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intracellular Signaling Cassette TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Fas Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Primary Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Phosphorylation Death Effector Domain Binding Positive Regulation Of Phosphorylation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Factor AP-1 Complex Receptor Serine/threonine Kinase Binding Forebrain Morphogenesis Response To Steroid Hormone Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of RNA Metabolic Process Synapse Maturation Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Response To Immobilization Stress Response To Muscle Stretch SMAD Protein Signal Transduction R-SMAD Binding Negative Regulation Of Neuron Projection Development Regulation Of Primary Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Proteolysis Alpha-2B Adrenergic Receptor Binding Developmental Process Response To Mechanical Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Medium-term Memory Integrated Stress Response Signaling Cellular Response To Prolactin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1 Response To Cocaine Negative Regulation Of Cell Projection Organization Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Proteolysis Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Axonogenesis Cell Death Apoptotic Process Cytosolic MRNA Polyadenylation Alpha-2C Adrenergic Receptor Binding Animal Organ Development Programmed Cell Death
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