FADD and TNFRSF10A

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		FADD	TNFRSF10A
Name		Fas associated via death domain	TNF receptor superfamily member 10a
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Body Ripoptosome	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Membrane Raft
	Molecular Function	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Tumor Necrosis Factor Receptor Superfamily Binding Receptor Serine/threonine Kinase Binding Signaling Adaptor Activity Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Caspase Binding	Protease Binding Death Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding TRAIL Binding
	Biological Process	Positive Regulation Of Cytokine Production Kidney Development Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Positive Regulation Of Adaptive Immune Response Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Response To Cocaine Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Lymph Node Development Spleen Development Thymus Development Positive Regulation Of Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Death-inducing Signaling Complex Assembly Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Necroptotic Signaling Pathway Defense Response To Other Organism Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand TRIF-mediated programmed cell death Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Regulation of necroptotic cell death Dimerization of procaspase-8 FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Defective RIPK1-mediated regulated necrosis	Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
GWAS		Diverticular disease ( 30177863 )	Advanced age-related macular degeneration ( 26691988 ) Age-related macular degeneration ( 21909106 23455636 ) Attention deficit hyperactivity disorder ( 20732625 ) Central serous retinopathy ( 31872073 ) Early age-related macular degeneration ( 32843070 )
Interacting Genes		57 interacting genes: ABCA1 ANK3 ATG5 BTG1 CASP10 CASP8 CASP8AP2 CDC20 CDH1 CFLAR CSNK1A1 DAP3 DAPK1 DDIT4L DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 NUTM2F PARK7 PEA15 PIDD1 PIN1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RNF4 RYBP SDCBP STAT1 STUB1 TAB1 TCEA2 TNFRSF10A TNFRSF10B TRADD TRAF2 TRAF6 TRIM21 UBE2I XPO5 ZCCHC12 ZMYM5	15 interacting genes: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD
Entrez ID		8772	8797
HPRD ID		03909	04679
Ensembl ID		ENSG00000168040	ENSG00000104689
Uniprot IDs		Q13158	O00220
PDB IDs		1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9 6ACI 7LXC 8YBX 8YD7 8YD8 8YNI	5CIR
GO Terms Enriched among Interactors		Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular Signal Transduction Death Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Apoptotic Process Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Programmed Cell Death Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasm Canonical NF-kappaB Signal Transduction Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Ripoptosome Regulation Of Protein Modification Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Intracellular Signaling Cassette TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Fas Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Tumor Necrosis Factor Receptor Binding Regulation Of Primary Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Phosphorylation Death Effector Domain Binding Positive Regulation Of Phosphorylation	Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Death Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process TRAIL Binding Positive Regulation Of Programmed Cell Death Ripoptosome Positive Regulation Of Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Necroptotic Process Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Positive Regulation Of Defense Response Positive Regulation Of Myeloid Cell Differentiation Death Domain Binding Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Regulation Of Myeloid Leukocyte Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Death Effector Domain Binding Regulation Of Programmed Necrotic Cell Death