DCLK1

Description		doublecortin like kinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Nervous System Development Central Nervous System Development Response To Virus Endosomal Transport Cell Differentiation Protein Localization To Nucleus Intracellular Signal Transduction Axon Extension
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Familial squamous cell lung carcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595) Interleukin-10 levels ( 22205395) Obesity-related traits ( 23251661) Optic cup area ( 25631615 28073927 31798171) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Post bronchodilator FEV1 ( 26634245) Vertical cup-disc ratio ( 20548946 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		4 interacting genes: APP CDC23 EFHC2 VPS26C
Entrez ID		9201
HPRD ID		09202
Ensembl ID		ENSG00000133083
Uniprot IDs		A0A9L9PXT2 B7Z5K4 O15075 Q5VZY9
PDB IDs		1MFW 1MG4 1UF0 5JZJ 5JZN 6KYQ 6KYR 7F3G 7KX6 7KX8 7KXW
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Metaphase/anaphase Transition Of Mitotic Cell Cycle Heparan Sulfate Binding Signaling Receptor Activator Activity Metaphase/anaphase Transition Of Cell Cycle Peptidase Activator Activity Cellular Response To Manganese Ion Positive Regulation Of Cell Cycle Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
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