NRBF2

Name	nuclear receptor binding factor 2
Structure
Novel Interactors	1 novel interactors: ARID5B
Interactors	15 interactors: C1orf216 CCNC CDC23 HNF4A IKBKG KDM1A PPARA PRKAA2 RARA RHOU RPTOR RXRA SHANK3 THRB TSC1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Autophagosome Cytoplasmic Vesicle Phosphatidylinositol 3-kinase Complex, Class III
	Molecular Function	Protein Binding
	Biological Process	Autophagy Response To Endoplasmic Reticulum Stress
GWAS	Atrial fibrillation ( 30061737 ) Fasting glucose ( 34059833 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Macular telangiectasia type 2 ( 33654266 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 24026423 ) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 ) Red blood cell count ( 32888494 ) Schizophrenia ( 30285260 28991256 ) Triglyceride levels ( 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Entrez ID	29982
HPRD ID	11401
Ensembl ID	ENSG00000148572
Uniprot IDs	Q96F24
PDB IDs	4ZEY
GO Terms Enriched among Interactors ?	Nuclear Receptor Activity Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Cell Size Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of ATP Metabolic Process RNA Polymerase II Transcription Regulator Complex Response To Monosaccharide Hormone-mediated Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Response To Carbohydrate Negative Regulation Of Hepatocyte Apoptotic Process Transcription Coactivator Binding Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleoplasm Regulation Of Glycolytic Process Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Intracellular Signal Transduction Cellular Response To Starvation MRNA Transcription TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Positive Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP Metabolic Process Cellular Response To Carbohydrate Stimulus Response To Starvation Sequence-specific DNA Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Chromatin Binding Negative Regulation Of Biosynthetic Process Response To Nutrient Levels Regulation Of Purine Nucleotide Metabolic Process