CD38 and FCGR3A

Number of citations of the paper that reports this interaction (PMID 11895784)
6

Data Source:
HPRD (in vitro)

		CD38	FCGR3A
Gene Name		CD38 molecule	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	NAD+ Nucleosidase Activity Transferase Activity Phosphorus-oxygen Lyase Activity NAD(P)+ Nucleosidase Activity	IgG Binding
	Biological Process	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long Term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Immune Response
Pathways			Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		6 interactors: CBL CD4 CD9 FCGR3A LCK PECAM1	15 interactors: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PTPRC SHC1 SYK ZAP70 ZBTB25
Entrez ID		952	2214
HPRD ID		00116	00903
Ensembl ID			ENSG00000203747
Uniprot IDs		P28907	E9PG94 M9MML0 P08637
PDB IDs		1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4F45 4F46	3AY4 3SGJ 3SGK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cell Activation Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Positive Regulation Of JAK-STAT Cascade Blood Coagulation Positive Regulation Of Signal Transduction Hemostasis Regulation Of Immune System Process Platelet Degranulation Immune Response-regulating Signaling Pathway T Cell Costimulation Regulation Of Cellular Ketone Metabolic Process Regulation Of Defense Response To Virus Regulation Of JAK-STAT Cascade Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Body Fluid Levels Wound Healing T Cell Receptor Signaling Pathway Response To Stress Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Antigen Receptor-mediated Signaling Pathway Diapedesis Positive Regulation Of Protein Phosphorylation T Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Phosphorylation Immune System Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of T Cell Activation	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Activation Immune Response Positive Regulation Of Immune System Process Response To Stress Cell Activation Regulation Of Cell Activation Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion B Cell Receptor Signaling Pathway Locomotion T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation T Cell Differentiation Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Alpha-beta T Cell Proliferation Blood Coagulation Hemostasis Positive Regulation Of T Cell Differentiation Signal Transduction Lymphocyte Differentiation Leukocyte Activation Positive Regulation Of Lymphocyte Differentiation Cell Migration Regulation Of Cellular Ketone Metabolic Process Beta Selection Phagocytosis
Tagcloud ?		alters apl cd18 changing coexpressed confirms develops engineered fuses heterodimerize hl60 leucine lost nb4 pml proline promyelocytic r4 rar rares relapsed relieved repressed retain retains retinoid subclone subclones unrearranged	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?		alters apl cd18 changing coexpressed confirms develops engineered fuses heterodimerize hl60 leucine lost nb4 pml proline promyelocytic r4 rar rares relapsed relieved repressed retain retains retinoid subclone subclones unrearranged	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?