CD38 and FCGR3A

Number of citations of the paper that reports this interaction (PubMedID 11895784)
0

Data Source:
HPRD (in vitro)

		CD38	FCGR3A
Description		CD38 molecule	Fc gamma receptor IIIa
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Nuclear Membrane Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Fc-gamma Receptor III Complex Extracellular Exosome
	Molecular Function	Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphorus-oxygen Lyase Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Protein Binding IgG Receptor Activity Low-affinity IgG Receptor Activity IgG Binding Immune Receptor Activity
	Biological Process	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Neuron Projection Development Artery Smooth Muscle Contraction NAD+ Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Cytokine B Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long-term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway	Antibody-dependent Cellular Cytotoxicity T Cell Mediated Cytotoxicity Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Protein Import Calcium-mediated Signaling Natural Killer Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Proliferation Fc-gamma Receptor Signaling Pathway Macrophage Activation Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Transmembrane Transport Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways		Nicotinate metabolism	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Daratumumab Isatuximab Mezagitamab	Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab Amivantamab
Diseases			NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
GWAS		Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 27182965 28892059)	Alanine aminotransferase levels ( 33547301) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Monocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 23830517 30498034) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908)
Interacting Genes		6 interacting genes: CBL CD4 CD9 FCGR3A LCK PECAM1	20 interacting genes: APCS APP CD247 CD38 CD4 CFTR FCER1G FCGR1A GP6 IGHG1 LCK LXN PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25
Entrez ID		952	2214
HPRD ID		00116	00903
Ensembl ID		ENSG00000004468	ENSG00000203747
Uniprot IDs		B4E006 P28907	H0Y755 P08637
PDB IDs		1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4CMH 4F45 4F46 4OGW 4TMF 4XJS 4XJT 5F1K 5F1O 5F21 6EDR 6VUA 7DHA 7DUO 7VKE 8BYU 8D0M 8IL3 8P8C 8VAU 9GOX 9GOY	3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5 7SEG 7URU
Enriched GO Terms of Interacting Partners?		Platelet Alpha Granule Membrane Membrane Raft External Side Of Plasma Membrane Plasma Membrane Cell Activation Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Leukocyte Degranulation Protein Tyrosine Kinase Binding Phosphotyrosine Residue Binding Cell Adhesion Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Lymphocyte Activation Clathrin-coated Endocytic Vesicle Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Positive Regulation Of Cell Activation Helper T Cell Enhancement Of Adaptive Immune Response Platelet Activation Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Endocytosis Positive Regulation Of MAPK Cascade Lymphocyte Activation Regulated Exocytosis Response To Methamphetamine Hydrochloride Regulation Of Cell-cell Adhesion Low-affinity IgG Receptor Activity Immune Receptor Activity Endothelial Cell-matrix Adhesion Regulation Of Lymphocyte Activation Response To Ethanol Symbiont Entry Into Host Cell Cell Recognition Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Activation Myoblast Fusion Involved In Skeletal Muscle Regeneration Fc-gamma Receptor III Complex Import Into Cell Regulation Of Rap Protein Signal Transduction Membrane Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation CD8 Receptor Binding Positive Regulation Of Protein Localization To Cell-cell Junction	Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Activation Adaptive Immune Response Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Complex Gamma-delta T Cell Activation Leukocyte Activation Activation Of Immune Response T Cell Differentiation Immune System Process Positive Regulation Of Endocytosis Positive Regulation Of MAPK Cascade Lymphocyte Activation T Cell Selection Defense Response To Bacterium T Cell Activation Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium-mediated Signaling Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Leukocyte Differentiation Defense Response Regulation Of Phagocytosis Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Vesicle-mediated Transport Response To Stress Immunoglobulin Mediated Immune Response Membrane Raft Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cytokine Production Plasma Membrane
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