CUBN and LGALS3

Number of citations: 0 (PubMedID 11856751)
Data Source: HPRD (in vitro)

		CUBN	LGALS3
Name		cubilin	galectin 3
Structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Brush Border Clathrin-coated Pit Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Cell Projection Membrane Brush Border Membrane Microvillus Membrane Lysosomal Lumen Receptor Complex Apical Part Of Cell Extracellular Exosome	Immunological Synapse Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Cobalamin Binding Signaling Receptor Activity Cargo Receptor Activity Protein Homodimerization Activity Metal Ion Binding	RNA Binding Protein Phosphatase Inhibitor Activity Protein Binding IgE Binding Protein Phosphatase Binding Carbohydrate Binding Signaling Receptor Inhibitor Activity Chemoattractant Activity Laminin Binding Disaccharide Binding Oligosaccharide Binding Molecular Condensate Scaffold Activity Receptor Ligand Inhibitor Activity
	Biological Process	Tissue Homeostasis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cobalamin Metabolic Process Response To Bacterium Protein Transport Cobalamin Transport Lipoprotein Transport Establishment Of Localization In Cell	Immune System Process Monocyte Chemotaxis MRNA Processing RNA Splicing Cell Differentiation Neutrophil Chemotaxis Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Killing Of Cells Of Another Organism Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis NK T Cell Activation Negative Regulation Of NK T Cell Activation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Vitamin D (calciferol) metabolism Defective AMN causes MGA1 Defective CUBN causes MGA1 HDL clearance Uptake of dietary cobalamins into enterocytes	Neutrophil degranulation Advanced glycosylation endproduct receptor signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX2 regulates genes involved in differentiation of myeloid cells
Drugs		Hydroxocobalamin	2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Lactose
GWAS		Binge eating behaviour in bipolar disorder ( 29391396 ) Bipolar disorder (early vs late onset) ( 34016946 ) Cholesterol, total ( 24097068 ) Colorectal cancer ( 25990418 ) Folate pathway vitamin levels ( 19744961 19303062 ) High density lipoprotein cholesterol levels ( 30498476 ) Homocysteine levels ( 23824729 ) Metabolite levels ( 23823483 ) Microalbuminuria ( 26631737 31511532 ) Molybdenum levels ( 26025379 ) Platelet distribution width ( 27863252 ) Plateletcrit ( 32888494 ) Proteinuria ( 30476138 ) Proteinuria (mild) ( 30476138 ) Proteinuria (moderate to severe) ( 30476138 ) Quantitative traits ( 19197348 ) Superior temporal gyrus volume ( 31530798 ) Total cholesterol levels ( 28334899 ) Total grey matter volume ( 31530798 ) Urate levels ( 31578528 ) Urinary albumin excretion ( 30220432 21355061 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 27650483 31511532 26631737 31630189 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 ) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737 ) Vitamin B levels in ischemic stroke ( 25147783 ) Whole-brain volume ( 21116278 )	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Leukoderma in response to rhododendrol ( 32558222 ) Protein biomarker ( 23056639 ) Testicular germ cell tumor ( 28604728 )
Interacting Genes		9 interacting genes: ALB BRCA1 CBL CBLIF GC LGALS3 LRP2 SCGB1A1 TF	32 interacting genes: ANXA1 APP C1GALT1C1 CRX CSNK1A1 CSNK2A1 CSNK2A2 CUBN ELN FCGR2A GEMIN4 GOLGA2 INCA1 KIF16B LGALS3BP LIM2 LINC00632 MCAM MCPH1 MEFV MMP2 MYOC PPIG PRR13 SNCA SS18L1 SUFU TRIM17 TRIM22 TRIM23 TRIM6 ZFTRAF1
Entrez ID		8029	3958
HPRD ID		04296	01090
Ensembl ID		ENSG00000107611	ENSG00000131981
Uniprot IDs		O60494	A0A024R693 P17931
PDB IDs		3KQ4 6GJE	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6RZF 6RZG 6RZH 6RZI 6RZJ 6RZK 6RZL 6RZM 6TF6 6TF7 6Y4C 6Y78 6ZVF 7BE3 7CXA 7DF5 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX 8BZ3 8ITX 8ITZ 8OJI 8OJK 8OJM 8OJO 8PBF 8PF9 8PFF 8PPN 8RMT 8RMU 8RMV 8RR7 8RR8 8RR9 8RRA 8RRB 8RRC 8RRE 8RRF 8RRG 8S67 8YMD 8Z1S 8Z1T 8Z25 8ZUV
GO Terms Enriched among Interactors		Vitamin Transport Cobalamin Transport Blood Microparticle Extracellular Space Vitamin D Metabolic Process Vitamin Transmembrane Transport Extracellular Region Extracellular Exosome Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Programmed Cell Death Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Process Protein Autoubiquitination BRCA1-BARD1 Complex Positive Regulation Of Receptor-mediated Endocytosis Response To Growth Factor Regulation Of Endocytosis Calcidiol Binding Lysosomal Lumen Apical Plasma Membrane Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Folate Import Across Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Clathrin-coated Pit Endocytic Vesicle Polychlorinated Biphenyl Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding SH3 Domain Binding Male Gonad Development Cargo Receptor Ligand Activity Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Folate Transmembrane Transport Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Response To Nutrient Levels Regulation Of Receptor-mediated Endocytosis Transmembrane Transport Response To Stress BRCA1-B Complex Regulation Of Rap Protein Signal Transduction Response To Ozone Response To Silicon Dioxide	Regulation Of Autophagy Positive Regulation Of Autophagy Protein Kinase CK2 Complex Positive Regulation Of Catabolic Process Negative Regulation Of Catabolic Process Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Defense Response Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Response To Interleukin-1 Regulation Of Proteolysis Protein Tetramerization Regulation Of Protein Catabolic Process Regulation Of Neurotransmitter Uptake Ubiquitin Protein Ligase Activity Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Defense Response Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Inflammatory Response Response To Other Organism Vesicle-mediated Transport Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Identical Protein Binding Negative Regulation Of Autophagy Regulation Of Receptor Recycling