CUBN and SCGB1A1

Number of citations of the paper that reports this interaction (PMID 11278724)
9

Data Source:
HPRD (in vivo)

		CUBN	SCGB1A1
Gene Name		cubilin (intrinsic factor-cobalamin receptor)	secretoglobin, family 1A, member 1 (uteroglobin)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Coated Pit Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Brush Border Membrane Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Space Nuclear Envelope Rough Endoplasmic Reticulum Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transporter Activity Calcium Ion Binding Protein Binding Cobalamin Binding Protein Homodimerization Activity	Protein Binding Phospholipase A2 Inhibitor Activity
	Biological Process	Tissue Homeostasis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cobalamin Metabolic Process Cobalamin Transport Lipoprotein Metabolic Process Vitamin D Metabolic Process Lipoprotein Transport Small Molecule Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Female Pregnancy Embryo Implantation Response To Xenobiotic Stimulus Response To Ozone Response To Lipopolysaccharide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Response To Silicon Dioxide Response To Cytokine Negative Regulation Of T Cell Proliferation Response To Drug Negative Regulation Of Catalytic Activity Regulation Of MRNA Stability Regulation Of Inflammatory Response Response To Glucocorticoid Response To Fibroblast Growth Factor
Pathways		Lipoprotein metabolism Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Lipid digestion, mobilization, and transport Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Metabolism of steroid hormones and vitamin D Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism HDL-mediated lipid transport Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Vitamin D (calciferol) metabolism Defects in vitamin and cofactor metabolism
Drugs		Hydroxocobalamin
Diseases
GWAS		Folate pathway vitamin levels ( 19303062 19744961) MRI atrophy measures ( 21116278) Quantitative traits ( 19197348) Urinary albumin excretion ( 21355061)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		9 interactors: ALB BRCA1 CBL GC GIF LGALS3 LRP2 SCGB1A1 TF	5 interactors: CUBN FN1 LMBR1L LRP2 TRIM32
Entrez ID		8029	7356
HPRD ID		04296	01884
Ensembl ID		ENSG00000107611	ENSG00000149021
Uniprot IDs		O60494	P11684
PDB IDs		3KQ4
Enriched GO Terms of Interacting Partners?		Vitamin Metabolic Process Vitamin D Metabolic Process Steroid Metabolic Process Vitamin Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Retina Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Platelet Degranulation Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Histone H4-K16 Acetylation Blood Coagulation Hemostasis Negative Regulation Of Signal Transduction Response To Stress Negative Regulation Of T Cell Activation Response To Steroid Hormone Negative Regulation Of Signaling Negative Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Tumor Necrosis Factor Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Histone H3-K9 Acetylation Glucosylceramide Catabolic Process Maintenance Of Mitochondrion Location Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Small Molecule Metabolic Process Lipid Metabolic Process Regulation Of Cytokine Production Response To Tumor Necrosis Factor Regulation Of Body Fluid Levels Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Mononuclear Cell Migration Response To Silicon Dioxide Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Response To Organic Substance Wound Healing Response To Stimulus Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Mononuclear Cell Migration Response To Glucocorticoid Negative Regulation Of Leukocyte Activation	Vitamin D Metabolic Process Vesicle-mediated Transport Endocytosis Vitamin Metabolic Process Positive Regulation Of Cell Growth Calcium-independent Cell-matrix Adhesion Positive Regulation Of Growth Steroid Metabolic Process Cobalamin Transport Positive Regulation Of Proteolysis Positive Regulation Of Neuron Differentiation Response To Light Stimulus Alcohol Metabolic Process Regulation Of Cell Growth Receptor-mediated Endocytosis Integrin Activation Positive Regulation Of Neurogenesis Negative Regulation Of Viral Release From Host Cell Response To Radiation Cobalamin Metabolic Process Lipoprotein Transport Positive Regulation Of Cell Development Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of Neuron Differentiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Tagcloud ?		accordingly advocate amn amnionless b12 coexpressed coreceptor correct critically cubilin endocytosis extremely glomerular ileum interdependency internalization lacks localize lrp2 malabsorption megalin mutually proteinuria suffer surprisingly transmembrane tubules ultrafiltrate vitamin	bmp4 branching catenin cc10 coactivator determination disrupted distal embryonic epicardial epithelium ex fgf10 genetically hallmarks histology iq1 lung lungs morphogenesis pharmacologically proximal proximalized proximalizes reinitiated reversible sox2 usage utero
Tagcloud (Difference) ?		accordingly advocate amn amnionless b12 coexpressed coreceptor correct critically cubilin endocytosis extremely glomerular ileum interdependency internalization lacks localize lrp2 malabsorption megalin mutually proteinuria suffer surprisingly transmembrane tubules ultrafiltrate vitamin	bmp4 branching catenin cc10 coactivator determination disrupted distal embryonic epicardial epithelium ex fgf10 genetically hallmarks histology iq1 lung lungs morphogenesis pharmacologically proximal proximalized proximalizes reinitiated reversible sox2 usage utero
Tagcloud (Intersection) ?