PTPN22 and CD247

Number of citations of the paper that reports this interaction (PMID 16461343)
57

Data Source:
HPRD (in vivo)

		PTPN22	CD247
Gene Name		protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	CD247 molecule
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Kinase Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Dephosphorylation T Cell Differentiation Regulation Of Natural Killer Cell Proliferation Peptidyl-tyrosine Dephosphorylation Phosphoanandamide Dephosphorylation Regulation Of Innate Immune Response Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Crohn's disease ( 18587394 21102463 23128233) Hypothyroidism ( 22493691) Myasthenia gravis ( 23055271) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 17804836 18794853 17554300 20453842 19503088) Type 1 diabetes ( 17632545 19430480 17554260 17554300 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)	Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		9 interactors: CBL CD247 CD3E CSK GRB2 LCK PRKCD VAV1 ZAP70	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		26191	919
HPRD ID		06100	01729
Ensembl ID		ENSG00000134242	ENSG00000198821
Uniprot IDs		B4DZW8 Q9Y2R2	P20963
PDB IDs		2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Cell Activation Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Innate Immune Response Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune System Process Immune Response Defense Response Lymphocyte Activation Blood Coagulation Hemostasis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Leukocyte Activation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		aitd antigens autoimmunity breakdown cd28 cd40 ctla4 develops discrepancy fcrl3 happen hashimoto humoral hyperthyroidism hypothyroidism il2ra immunogenicity immunoregulatory infiltrating insults iodine multifactorial parity preponderance thymus thyroglobulin thyroid thyrotropin wrong	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		aitd antigens breakdown cd28 cd40 ctla4 develops discrepancy fcrl3 happen hashimoto humoral hyperthyroidism hypothyroidism il2ra immunogenicity immunoregulatory infiltrating insults iodine multifactorial parity preponderance thymus thyroglobulin thyroid thyrotropin wrong	already annotation annotations b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?		autoimmunity