NOS1 and HMOX1

Number of citations of the paper that reports this interaction (PMID 11849436)
5

Data Source:
HPRD (in vivo)

		NOS1	HMOX1
Gene Name		nitric oxide synthase 1 (neuronal)	heme oxygenase (decycling) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol Cytoskeleton Sarcoplasmic Reticulum Sarcolemma Dendritic Spine Protein Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Ryanodine Receptor Complex	Extracellular Space Nucleus Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Ion Channel Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Signal Transducer Activity Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Coagulation Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Exogenous Drug Catabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Phagosome Maturation Positive Regulation Of The Force Of Heart Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Cellular Response To Nutrient Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Hydrogen Peroxide Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Small Molecule Metabolic Process Positive Regulation Of Chemokine Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Vasodilation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Homooligomerization Iron Ion Homeostasis Transmembrane Transport Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase	Iron uptake and transport Metabolism of porphyrins Heme degradation
Drugs		L-Citrulline L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Formic Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide N-Isopropyl-N\'-Hydroxyguanidine N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin N-Butyl-N\'-Hydroxyguanidine Alpha-D-Mannose S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea Heme N-Omega-Hydroxy-L-Arginine Flavin-Adenine Dinucleotide Riboflavin Monophosphate N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine 2\'-Monophosphoadenosine 5\'-Diphosphoribose S-Ethyl-N-Phenyl-Isothiourea N5-(1-Imino-3-Butenyl)-L-Ornithine 5-N-Allyl-Arginine Nitroarginine N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine	NADH Formic Acid Biliverdine Ix Alpha 12-Phenylheme Heme 2-Phenylheme Verdoheme 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		33 interactors: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PTPN6 PTPRN RASD1 SNTA1 STUB1 SUMO1 SYN1 VAC14 ZDHHC23	10 interactors: AKT1 ASL BLVRB CCDC155 CPSF1 NOS1 POR POT1 TERF1 TUT1
Entrez ID		4842	3162
HPRD ID		01226	00782
Ensembl ID		ENSG00000089250	ENSG00000100292
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	P09601 Q6FH11
PDB IDs			1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM
Enriched GO Terms of Interacting Partners?		Regulation Of Heart Contraction Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling Regulation Of Catalytic Activity Regulation Of Ion Transport Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Regulation Of Signaling Regulation Of Striated Muscle Contraction Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Regulation Of Phosphorus Metabolic Process Signaling Cell Communication Regulation Of Cellular Localization Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Chemical Homeostasis Regulation Of Metabolic Process Negative Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Signal Transduction Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metal Ion Homeostasis Synaptic Transmission Regulation Of Oxidoreductase Activity Regulation Of Phosphorylation Activation Of Adenylate Cyclase Activity Cellular Response To Stimulus Cellular Cation Homeostasis Homeostatic Process Cellular Calcium Ion Homeostasis Vasoconstriction Cellular Ion Homeostasis Regulation Of Blood Pressure Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Signal Transduction Cytosolic Calcium Ion Homeostasis Cellular Localization Metal Ion Homeostasis Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport	Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Arginine Catabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Catalytic Activity Regulation Of Telomere Maintenance Via Telomerase Reactive Oxygen Species Metabolic Process Nitric Oxide Biosynthetic Process Positive Regulation Of Organelle Organization Regulation Of Telomerase Activity MRNA Cleavage Arginine Metabolic Process Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Monooxygenase Activity MRNA Polyadenylation Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Sodium Ion Transport RNA Polyadenylation Positive Regulation Of Oxidoreductase Activity Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Cellular Metabolic Process Negative Regulation Of Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Sodium Ion Transport Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Telomere Maintenance Regulation Of Organelle Organization Negative Regulation Of Protein Processing Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Nitrate Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Cellular Organofluorine Metabolic Process Positive Regulation Of DNA Strand Elongation Chromosome Localization To Nuclear Envelope Involved In Synapsis Nitric Oxide Catabolic Process Catabolic Process Regulation Of Oxidoreductase Activity MRNA 3'-end Processing Negative Regulation Of Hydrolase Activity
Tagcloud ?		adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing	alters antioxidative bax cytotoxicity demonstrating ebp endonuclease endoplasmic expressions heme homologous immunoglobulin induces inositol messenger morphological nrf2 overproduction oxygenase reduces requiring simultaneously splicing stimulates tcp trichlorophenol triggered upregulates xbp1
Tagcloud (Difference) ?		adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing	alters antioxidative bax cytotoxicity demonstrating ebp endonuclease endoplasmic expressions heme homologous immunoglobulin induces inositol messenger morphological nrf2 overproduction oxygenase reduces requiring simultaneously splicing stimulates tcp trichlorophenol triggered upregulates xbp1
Tagcloud (Intersection) ?