NOS1 and NOSIP

Number of citations of the paper that reports this interaction (PMID 15548660)
14

Data Source:
HPRD (in vivo)

		NOS1	NOSIP
Gene Name		nitric oxide synthase 1 (neuronal)	nitric oxide synthase interacting protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Mitochondrion Cytosol Cytoskeleton Sarcoplasmic Reticulum Sarcolemma Dendritic Spine Protein Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Ryanodine Receptor Complex	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Ion Channel Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Coagulation Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Exogenous Drug Catabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Phagosome Maturation Positive Regulation Of The Force Of Heart Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Generation Of L-type Calcium Current	Negative Regulation Of Catalytic Activity Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase	Metabolism of nitric oxide NOSIP mediated eNOS trafficking eNOS activation and regulation
Drugs		L-Citrulline L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Formic Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide N-Isopropyl-N\'-Hydroxyguanidine N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin N-Butyl-N\'-Hydroxyguanidine Alpha-D-Mannose S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea Heme N-Omega-Hydroxy-L-Arginine Flavin-Adenine Dinucleotide Riboflavin Monophosphate N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine 2\'-Monophosphoadenosine 5\'-Diphosphoribose S-Ethyl-N-Phenyl-Isothiourea N5-(1-Imino-3-Butenyl)-L-Ornithine 5-N-Allyl-Arginine Nitroarginine N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PTPN6 PTPRN RASD1 SNTA1 STUB1 SUMO1 SYN1 VAC14 ZDHHC23	3 interactors: KPNA1 NOS1 NOS3
Entrez ID		4842	51070
HPRD ID		01226	17642
Ensembl ID		ENSG00000089250	ENSG00000142546
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	Q9Y314
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Heart Contraction Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling Regulation Of Catalytic Activity Regulation Of Ion Transport Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Regulation Of Signaling Regulation Of Striated Muscle Contraction Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Regulation Of Phosphorus Metabolic Process Signaling Cell Communication Regulation Of Cellular Localization Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Chemical Homeostasis Regulation Of Metabolic Process Negative Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Signal Transduction Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metal Ion Homeostasis Synaptic Transmission Regulation Of Oxidoreductase Activity Regulation Of Phosphorylation Activation Of Adenylate Cyclase Activity Cellular Response To Stimulus Cellular Cation Homeostasis Homeostatic Process Cellular Calcium Ion Homeostasis Vasoconstriction Cellular Ion Homeostasis Regulation Of Blood Pressure Calcium Ion Homeostasis Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Signal Transduction Cytosolic Calcium Ion Homeostasis Cellular Localization Metal Ion Homeostasis Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport	Arginine Catabolic Process Positive Regulation Of Guanylate Cyclase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nitric Oxide Mediated Signal Transduction Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Potassium Ion Transport Regulation Of CGMP Biosynthetic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of The Force Of Heart Contraction Regulation Of CGMP Metabolic Process Positive Regulation Of Vasodilation Negative Regulation Of Calcium Ion Transport Phagosome Maturation Regulation Of Vasodilation Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Regulation Of Cyclase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Translation Negative Regulation Of Ion Transport Epithelial Cell Migration Epithelium Migration Interaction With Host Reactive Oxygen Species Metabolic Process Response To Heat Cellular Amino Acid Catabolic Process Second-messenger-mediated Signaling Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Heart Contraction Regulation Of Blood Pressure Ameboidal-type Cell Migration Response To Temperature Stimulus Regulation Of Calcium Ion Transport Carboxylic Acid Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Smooth Muscle Hyperplasia Negative Regulation Of Serotonin Uptake Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Muscle System Process Regulation Of Translation Alpha-amino Acid Metabolic Process Catabolic Process
Tagcloud ?		adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing
Tagcloud (Difference) ?		adenine afterload arrhythmias arrhythmogenic camkii cardiomyocyte cardiomyocytes cardiomyopathy contract contractility contraction counter diastole dinucleotide heartbeat hypertrophic imposes mechanochemotransduction mechanotransduction nicotinamide nnos nos3 nox2 ryanodine ryr sarcoplasmic sparks super transducing
Tagcloud (Intersection) ?