NOS1 and STUB1

Number of citations of the paper that reports this interaction (PubMedID 32591478)
41

Data Source:
BioGRID (enzymatic study)

		NOS1	STUB1
Description		nitric oxide synthase 1	STIP1 homology and U-box containing protein 1
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Caveola Endomembrane System Postsynaptic Density Membrane Sarcoplasmic Reticulum Z Disc T-tubule Protein-containing Complex Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Dendritic Spine Calyx Of Held Membrane Raft Synapse Perinuclear Region Of Cytoplasm Cell Periphery	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Protein Folding Chaperone Complex
	Molecular Function	Nitric-oxide Synthase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Peptidyl-cysteine S-nitrosylase Activity Transmembrane Transporter Binding Cadmium Ion Binding Metal Ion Binding Calcium-dependent Protein Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity R-SMAD Binding
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport L-arginine Catabolic Process Nitric Oxide Biosynthetic Process Potassium Ion Transport Calcium Ion Transport Striated Muscle Contraction Cell Communication Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Circulation Response To Heat Response To Hormone Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Metal Ion Transport Signaling Response To Lipopolysaccharide Multicellular Organismal Response To Stress Xenobiotic Catabolic Process Vasodilation Negative Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Blood Pressure Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Serotonin Uptake Establishment Of Localization In Cell Negative Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Postsynaptic Membrane Potential Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of The Force Of Heart Contraction Synaptic Signaling By Nitric Oxide Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Blood Circulation Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	MAPK Cascade Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway ERAD Pathway ERBB2 Signaling Pathway Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Stabilization Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Mitophagy Positive Regulation Of ERAD Pathway Negative Regulation Of Vascular Associated Smooth Muscle Contraction
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Ion homeostasis	Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Citrulline Donepezil Ketamine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Formic acid 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide 1-hydroxy-2-isopropylguanidine 7-Nitroindazole N-omega-propyl-L-arginine 2-butyl-1-hydroxyguanidine S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Flavin adenine dinucleotide Flavin mononucleotide N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Nicotinamide adenine dinucleotide phosphate S-Ethyl-N-Phenyl-Isothiourea [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium 5-N-Allyl-arginine Nitroarginine NXN-188 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Methylene blue
Diseases
GWAS		Anxiety ( 33859377) Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Depression ( 33859377) Disability (impaired activities of daily living) ( 31707593) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Schizophrenia ( 28991256 30285260)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		33 interacting genes: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PRKD1 PTPN6 PTPRN RASD1 SNTA1 STUB1 SYN1 VAC14 ZDHHC23	149 interacting genes: ABL1 ACD ADRM1 AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BBOX1 BCR BMPR1B CASP6 CCL28 CDK4 CDK9 CDKN1A CFTR CIP2A CRIP1 CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EGFR EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FXR1 GHR GPR37 GUCY1A1 GUCY1A2 HMGB1 HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 HUNK INSR JAK1 JOSD1 JOSD2 KHDRBS1 KPNA2 LRRK1 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 METTL14 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 OTUD3 PA2G4 PFN1 PKM PLK1 PMAIP1 POLB POT1 PPP3CA PRKACA PRKCZ PRKN PRMT1 PSMA3 PSMC2 PSMD1 PSMD2 PSMD4 RAF1 RFFL RGS17 RHBDF2 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SLC7A11-AS1 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNCA SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TP53 TP63 TP73 TPD52 TRAF6 TTN TXN2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W UNC45B VCP VDAC1 XIAP YTHDF2
Entrez ID		4842	10273
HPRD ID		01226	06232
Ensembl ID		ENSG00000089250	ENSG00000103266
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	Q9UNE7
PDB IDs		4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6CIC 6CID 6NG1 6NG2 6NG4 6NG5 6NG6 6NG7 6NG8 6NGA 6NGB 6NGC 6NGD 6NGE 6NGF 6NGH 6NGI 6NHB 6NHC 6PNA 6PNB 6PNC 6PND 6PNE 6PNF 6PNG 6PNH 6PO5 6PO7 6PO8 6PO9 6POA 6POB 6POC 6POT 7TS1 7TS2 7TS3 7TS4 7TS5 7TS6 7TS7 7TS8 7UAM 7US7 7US8 8BI8 8BI9 8FGF 8FGG 8FGH 8FGI 8FGJ 8FGK 8FGL 8FGM 8UFP 8UFQ	4KBQ 6EFK 6NSV 7TB1 8EHZ 8EI0 8F14 8F15 8F16 8F17 8FYU 8GCK 8SUV 9DRY
Enriched GO Terms of Interacting Partners?		Regulation Of System Process Regulation Of Blood Circulation Adrenergic Receptor Activity Regulation Of Muscle System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of Transport Regulation Of Heart Contraction Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction System Process Nitric-oxide Synthase Binding Alpha1-adrenergic Receptor Activity Regulation Of Tube Size Blood Vessel Diameter Maintenance Regulation Of Metal Ion Transport Muscle System Process Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Phosphorylation Regulation Of Heart Rate Regulation Of Multicellular Organismal Process Neuron-glial Cell Signaling Regulation Of Monoatomic Ion Transport Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Circulatory System Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Caveola Protein Phosphorylation Nitric-oxide Synthase Regulator Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus Neuromuscular Junction Positive Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Response To Cold Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Muscle Contraction Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Ubiquitin Protein Ligase Binding Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Intracellular Signal Transduction Cytosol Regulation Of Primary Metabolic Process Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Nucleus Cytoplasm Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Protein Modification Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleotide Binding Regulation Of Intracellular Signal Transduction Protein-containing Complex Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Post-translational Protein Modification Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Cellular Response To Stress Proteasomal Protein Catabolic Process
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