NOS1 and ZDHHC23

Number of citations of the paper that reports this interaction (PubMedID 15105416)
0

Data Source:
HPRD (in vitro, in vivo)

		NOS1	ZDHHC23
Description		nitric oxide synthase 1	zDHHC palmitoyltransferase 23
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Caveola Endomembrane System Postsynaptic Density Membrane Sarcoplasmic Reticulum Z Disc T-tubule Protein-containing Complex Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Dendritic Spine Calyx Of Held Membrane Raft Synapse Perinuclear Region Of Cytoplasm Cell Periphery	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane
	Molecular Function	Nitric-oxide Synthase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Peptidyl-cysteine S-nitrosylase Activity Transmembrane Transporter Binding Cadmium Ion Binding Metal Ion Binding Calcium-dependent Protein Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport L-arginine Catabolic Process Nitric Oxide Biosynthetic Process Potassium Ion Transport Calcium Ion Transport Striated Muscle Contraction Cell Communication Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Circulation Response To Heat Response To Hormone Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Metal Ion Transport Signaling Response To Lipopolysaccharide Multicellular Organismal Response To Stress Xenobiotic Catabolic Process Vasodilation Negative Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Blood Pressure Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Serotonin Uptake Establishment Of Localization In Cell Negative Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Postsynaptic Membrane Potential Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of The Force Of Heart Contraction Synaptic Signaling By Nitric Oxide Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Blood Circulation Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Protein Targeting To Membrane Protein Palmitoylation Protein Localization To Plasma Membrane
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Ion homeostasis
Drugs		Citrulline Donepezil Ketamine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Formic acid 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide 1-hydroxy-2-isopropylguanidine 7-Nitroindazole N-omega-propyl-L-arginine 2-butyl-1-hydroxyguanidine S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Flavin adenine dinucleotide Flavin mononucleotide N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Nicotinamide adenine dinucleotide phosphate S-Ethyl-N-Phenyl-Isothiourea [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium 5-N-Allyl-arginine Nitroarginine NXN-188 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Methylene blue
Diseases
GWAS		Anxiety ( 33859377) Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Depression ( 33859377) Disability (impaired activities of daily living) ( 31707593) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Schizophrenia ( 28991256 30285260)	Crohn's disease and psoriasis ( 22482804)
Interacting Genes		33 interacting genes: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PRKD1 PTPN6 PTPRN RASD1 SNTA1 STUB1 SYN1 VAC14 ZDHHC23	3 interacting genes: APP GLIS1 NOS1
Entrez ID		4842	254887
HPRD ID		01226	15717
Ensembl ID		ENSG00000089250	ENSG00000184307
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	A0A1W2PRJ8 B3KXV3 E9PAP7 Q8IYP9
PDB IDs		4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6CIC 6CID 6NG1 6NG2 6NG4 6NG5 6NG6 6NG7 6NG8 6NGA 6NGB 6NGC 6NGD 6NGE 6NGF 6NGH 6NGI 6NHB 6NHC 6PNA 6PNB 6PNC 6PND 6PNE 6PNF 6PNG 6PNH 6PO5 6PO7 6PO8 6PO9 6POA 6POB 6POC 6POT 7TS1 7TS2 7TS3 7TS4 7TS5 7TS6 7TS7 7TS8 7UAM 7US7 7US8 8BI8 8BI9 8FGF 8FGG 8FGH 8FGI 8FGJ 8FGK 8FGL 8FGM 8UFP 8UFQ
Enriched GO Terms of Interacting Partners?		Regulation Of System Process Regulation Of Blood Circulation Adrenergic Receptor Activity Regulation Of Muscle System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of Transport Regulation Of Heart Contraction Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction System Process Nitric-oxide Synthase Binding Alpha1-adrenergic Receptor Activity Regulation Of Tube Size Blood Vessel Diameter Maintenance Regulation Of Metal Ion Transport Muscle System Process Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Phosphorylation Regulation Of Heart Rate Regulation Of Multicellular Organismal Process Neuron-glial Cell Signaling Regulation Of Monoatomic Ion Transport Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Circulatory System Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Caveola Protein Phosphorylation Nitric-oxide Synthase Regulator Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus Neuromuscular Junction Positive Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Response To Cold Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Muscle Contraction Positive Regulation Of Cell Communication Positive Regulation Of Signaling	Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Neurotransmitter Uptake Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Calcium-mediated Signaling Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Synaptic Signaling By Nitric Oxide Peptidyl-cysteine S-nitrosylase Activity Positive Regulation Of Macromolecule Metabolic Process Membrane Raft Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Calcium Ion Transport Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of The Force Of Heart Contraction Cadmium Ion Binding
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